Identification of microRNAs involved in gefitinib resistance of non-small-cell lung cancer through the insulin-like growth factor receptor 1 signaling pathway

Multiple clinical and experimental studies have suggested that epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) may be effective at treating advanced non-small cell lung cancer (NSCLC), however, the molecular basis of primary resistance to EGFR-TKIs in NSCLC remains unclear. I...

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Veröffentlicht in:	Experimental and therapeutic medicine 2017-10, Vol.14 (4), p.2853-2862
Hauptverfasser:	Ma, Wei, Kang, Yanhong, Ning, Lanlan, Tan, Jie, Wang, Hanping, Ying, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug resistance Epidermal growth factor Inhibitor drugs Insulin-like growth factors Kinases Lung cancer Metastasis MicroRNAs Mutation Proteins Studies Targeted cancer therapy Tumors
Online-Zugang:	Volltext
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