Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis

Background: Ghrelin is the only orexigenic hormone known to stimulate food intake and promote obesity and insulin resistance. We recently showed that plasma ghrelin is controlled by butyrylcholinesterase (BChE), which has a strong impact on feeding and weight gain. BChE knockout (KO) mice are prone...

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Veröffentlicht in:	International Journal of Obesity 2017-09, Vol.41 (9), p.1413-1419
Hauptverfasser:	Chen, V P, Gao, Y, Geng, L, Brimijoin, S
Format:	Artikel
Sprache:	eng
Schlagworte:	42 42/109 631/378/1488/393 631/443/319/1488 631/443/319/1488/393 631/61/51/201 631/80/86 64/60 82 82/80 Animals Apnea - physiopathology Body composition Body weight Body weight gain Brain Butyrylcholinesterase - deficiency Butyrylcholinesterase - metabolism Butyrylcholinesterase - pharmacology Diet Disease Models, Animal Eating - drug effects Epidemiology Feeding Food Food intake Gene transfer Gene Transfer Techniques Ghrelin Ghrelin - drug effects Ghrelin - physiology Glucose Glucose tolerance Glucose tolerance test Health aspects Health Promotion and Disease Prevention High fat diet Homeostasis Hyperinsulinemia Insulin Insulin resistance Insulin Resistance - physiology Internal Medicine Intravenous administration Male Medicine Medicine & Public Health Metabolic Diseases Metabolism, Inborn Errors - physiopathology Mice Mice, Knockout Obesity Original original-article Public Health Rodents Signal Transduction - physiology Test procedures Viruses
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