Intranasal insulin treatment of an experimental model of moderate traumatic brain injury

Traumatic brain injury (TBI) results in learning and memory dysfunction. Cognitive deficits result from cellular and metabolic dysfunction after injury, including decreased cerebral glucose uptake and inflammation. This study assessed the ability of intranasal insulin to increase cerebral glucose up...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2017-09, Vol.37 (9), p.3203-3218
Hauptverfasser:	Brabazon, Fiona, Wilson, Colin M, Jaiswal, Shalini, Reed, John, Frey, William H, Byrnes, Kimberly R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Blood Glucose - analysis Brain Injuries, Traumatic - diagnostic imaging Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - physiopathology Fluorodeoxyglucose F18 - metabolism Glucose - metabolism Hippocampus - diagnostic imaging Hippocampus - drug effects Hippocampus - metabolism Insulin - administration & dosage Insulin - therapeutic use Magnetic Resonance Imaging Male Maze Learning - drug effects Memory - drug effects Microglia - drug effects Microglia - metabolism Motor Activity - drug effects Original Positron Emission Tomography Computed Tomography Rats Rats, Sprague-Dawley
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