A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1

The nutrient starvation-specific unconventional secretion of Acb1 in requires ESCRT-I, -II, and -III and Grh1. In this study, we report that another signal sequence lacking cytoplasmic protein, superoxide dismutase 1 (SOD1), and its mutant form linked to amyotrophic lateral sclerosis (ALS), is also...

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Veröffentlicht in:	The Journal of cell biology 2017-09, Vol.216 (9), p.2691-2700
Hauptverfasser:	Cruz-Garcia, David, Brouwers, Nathalie, Duran, Juan M, Mora, Gabriel, Curwin, Amy J, Malhotra, Vivek
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amyotrophic lateral sclerosis Baking yeast Coding Cytoplasm Mutation Nutrients Proteins Saccharomyces cerevisiae Secretion Superoxide dismutase Yeast
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