Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin
The vasodilatory mechanism of Nntroglycerin (NTG) is similar to sodium nitroprusside (SNP) in regard to action on guanosine 3'5'-monophosphate (cyclic GMP) via nitric oxide. However, it is unknown whether NTG can achieve the same magnitude of vasodilation in the forearm as SNP. Therefore,...
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| description | The vasodilatory mechanism of Nntroglycerin (NTG) is similar to sodium nitroprusside (SNP) in regard to action on guanosine 3'5'-monophosphate (cyclic GMP) via nitric oxide. However, it is unknown whether NTG can achieve the same magnitude of vasodilation in the forearm as SNP. Therefore, the purpose of the study was to evaluate the differences in forearm blood flow (FBF) and forearm vascular conductance (FVC) during escalating infusions of NTG vs. SNP at similar concentration doses and rates. We measured FBF using venous occlusion plethysmography (VOP) and Doppler ultrasound in eight young, healthy participants (mean age = 28 ± 2 yr) during four forearm volume (FAV)-specific doses (0.25, 0.5, 1, and 2 µg·100 ml FAV
·min
) of SNP and NTG infused via a brachial artery catheter. There was a significant difference in FVC of SNP vs. NTG only at the higher doses, as measured by VOP (14.9 ± 1.4 and 18.3 ± 1.5 vs. 11.6 ± 1.2 and 12.5 ± 1.2 ml/dl FAV
·min
·100 mmHg
). FVC as measured by Doppler ultrasound unadjusted for FAV was significantly different at the lowest and the higher two doses of SNP compared with NTG (202.1 ± 25.8, 329.4 ± 46.7, and 408 ± 63.5 vs. 142.9 ± 22.4, 217.2 ± 18.8, and 247.5 ± 18.2 ml·min
·100 mmHg
). SNP induces significantly higher vasodilatory actions compared with NTG. However, NTG is comparable in eliciting equivalent vasodilator effects to SNP during low concentration doses when measured by VOP. Importantly, for forearm pharmacology studies, NTG can elicit marked endothelium-independent forearm vasodilation.
We compared the vasodilatory capacities of NTG vs. SNP at similar concentration doses and rates into the forearm. Based on the results of the study, it may be feasible to use intra-arterial NTG as a measure of endothelial-independent vasodilator in research studies. However, NTG dosing may need to be higher if used as an endothelial-independent vasodilator due to significant differences in the vasodilatory effects during higher doses of SNP compared with NTG. |
| doi_str_mv | 10.1152/japplphysiol.00167.2017 |
| format | Article |
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·min
) of SNP and NTG infused via a brachial artery catheter. There was a significant difference in FVC of SNP vs. NTG only at the higher doses, as measured by VOP (14.9 ± 1.4 and 18.3 ± 1.5 vs. 11.6 ± 1.2 and 12.5 ± 1.2 ml/dl FAV
·min
·100 mmHg
). FVC as measured by Doppler ultrasound unadjusted for FAV was significantly different at the lowest and the higher two doses of SNP compared with NTG (202.1 ± 25.8, 329.4 ± 46.7, and 408 ± 63.5 vs. 142.9 ± 22.4, 217.2 ± 18.8, and 247.5 ± 18.2 ml·min
·100 mmHg
). SNP induces significantly higher vasodilatory actions compared with NTG. However, NTG is comparable in eliciting equivalent vasodilator effects to SNP during low concentration doses when measured by VOP. Importantly, for forearm pharmacology studies, NTG can elicit marked endothelium-independent forearm vasodilation.
We compared the vasodilatory capacities of NTG vs. SNP at similar concentration doses and rates into the forearm. Based on the results of the study, it may be feasible to use intra-arterial NTG as a measure of endothelial-independent vasodilator in research studies. However, NTG dosing may need to be higher if used as an endothelial-independent vasodilator due to significant differences in the vasodilatory effects during higher doses of SNP compared with NTG.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00167.2017</identifier><identifier>PMID: 28572495</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adult ; Blood flow ; Brachial Artery - drug effects ; Brachial Artery - metabolism ; Conductance ; Cyclic GMP ; Doppler effect ; Drugs ; Endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Female ; Forearm ; Forearm - blood supply ; Guanosine ; Humans ; Innovative Methodology ; Male ; Medical instruments ; Nitric oxide ; Nitric Oxide - metabolism ; Nitroglycerin ; Nitroglycerin - pharmacology ; Nitroprusside - pharmacology ; Occlusion ; Pharmacology ; Plethysmography ; Plethysmography - methods ; Regional Blood Flow - drug effects ; Sodium ; Sodium nitroprusside ; Ultrasound ; Vascular Resistance - drug effects ; Vasodilation ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology</subject><ispartof>Journal of applied physiology (1985), 2017-08, Vol.123 (2), p.402-406</ispartof><rights>Copyright © 2017 the American Physiological Society.</rights><rights>Copyright American Physiological Society Aug 2017</rights><rights>Copyright © 2017 the American Physiological Society 2017 American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-7aa77503bcae80194ca422e27d92117f368c6ffbc17562dc9b3b1af1ac9c50a83</citedby><cites>FETCH-LOGICAL-c445t-7aa77503bcae80194ca422e27d92117f368c6ffbc17562dc9b3b1af1ac9c50a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3038,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28572495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranadive, Sushant M</creatorcontrib><creatorcontrib>Eugene, Andy R</creatorcontrib><creatorcontrib>Dillon, Gabrielle</creatorcontrib><creatorcontrib>Nicholson, Wayne T</creatorcontrib><creatorcontrib>Joyner, Michael J</creatorcontrib><title>Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>The vasodilatory mechanism of Nntroglycerin (NTG) is similar to sodium nitroprusside (SNP) in regard to action on guanosine 3'5'-monophosphate (cyclic GMP) via nitric oxide. However, it is unknown whether NTG can achieve the same magnitude of vasodilation in the forearm as SNP. Therefore, the purpose of the study was to evaluate the differences in forearm blood flow (FBF) and forearm vascular conductance (FVC) during escalating infusions of NTG vs. SNP at similar concentration doses and rates. We measured FBF using venous occlusion plethysmography (VOP) and Doppler ultrasound in eight young, healthy participants (mean age = 28 ± 2 yr) during four forearm volume (FAV)-specific doses (0.25, 0.5, 1, and 2 µg·100 ml FAV
·min
) of SNP and NTG infused via a brachial artery catheter. There was a significant difference in FVC of SNP vs. NTG only at the higher doses, as measured by VOP (14.9 ± 1.4 and 18.3 ± 1.5 vs. 11.6 ± 1.2 and 12.5 ± 1.2 ml/dl FAV
·min
·100 mmHg
). FVC as measured by Doppler ultrasound unadjusted for FAV was significantly different at the lowest and the higher two doses of SNP compared with NTG (202.1 ± 25.8, 329.4 ± 46.7, and 408 ± 63.5 vs. 142.9 ± 22.4, 217.2 ± 18.8, and 247.5 ± 18.2 ml·min
·100 mmHg
). SNP induces significantly higher vasodilatory actions compared with NTG. However, NTG is comparable in eliciting equivalent vasodilator effects to SNP during low concentration doses when measured by VOP. Importantly, for forearm pharmacology studies, NTG can elicit marked endothelium-independent forearm vasodilation.
We compared the vasodilatory capacities of NTG vs. SNP at similar concentration doses and rates into the forearm. Based on the results of the study, it may be feasible to use intra-arterial NTG as a measure of endothelial-independent vasodilator in research studies. However, NTG dosing may need to be higher if used as an endothelial-independent vasodilator due to significant differences in the vasodilatory effects during higher doses of SNP compared with NTG.</description><subject>Adult</subject><subject>Blood flow</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - metabolism</subject><subject>Conductance</subject><subject>Cyclic GMP</subject><subject>Doppler effect</subject><subject>Drugs</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Female</subject><subject>Forearm</subject><subject>Forearm - blood supply</subject><subject>Guanosine</subject><subject>Humans</subject><subject>Innovative Methodology</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitroglycerin</subject><subject>Nitroglycerin - pharmacology</subject><subject>Nitroprusside - pharmacology</subject><subject>Occlusion</subject><subject>Pharmacology</subject><subject>Plethysmography</subject><subject>Plethysmography - methods</subject><subject>Regional Blood Flow - drug effects</subject><subject>Sodium</subject><subject>Sodium nitroprusside</subject><subject>Ultrasound</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasodilation</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r4zAQxcWyZZOm_Qq7hr304lQjWZZ8WVhC_0GhPbRnIctSo2BbXsku5NtXabIl7Wlg3m8eb3gI_QK8BGDkcqOGoR3W2-h8u8QYSr4kGPg3NE8qyaHE8B3NBWc450zwGTqNcZO4omDwA82IYJwUFZujx5XvBhVc9H3mbTauTfaqom9cq0Yftpmx1ugx7rTdduqy3o3BD2GK0TUJjsv95qXdahNcf4ZOrGqjOT_MBXq-vnpa3eb3Dzd3q7_3uU4ZxpwrxVM6WmtlBIaq0KogxBDeVASAW1oKXVpba-CsJI2ualqDsqB0pRlWgi7Qn73vMNWdabTpx6BaOQTXqbCVXjn5WendWr74V8mYoCWQZHBxMAj-32TiKDsXtWlb1Rs_RQkVZpxSIWhCf39BN34KfXovUSUXRBQlJIrvKR18jMHYjzCA5a41edyafG9N7lpLlz-Pf_m4-18TfQOONJnO</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Ranadive, Sushant M</creator><creator>Eugene, Andy R</creator><creator>Dillon, Gabrielle</creator><creator>Nicholson, Wayne T</creator><creator>Joyner, Michael J</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin</title><author>Ranadive, Sushant M ; Eugene, Andy R ; Dillon, Gabrielle ; Nicholson, Wayne T ; Joyner, Michael J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-7aa77503bcae80194ca422e27d92117f368c6ffbc17562dc9b3b1af1ac9c50a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Blood flow</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - metabolism</topic><topic>Conductance</topic><topic>Cyclic GMP</topic><topic>Doppler effect</topic><topic>Drugs</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Female</topic><topic>Forearm</topic><topic>Forearm - blood supply</topic><topic>Guanosine</topic><topic>Humans</topic><topic>Innovative Methodology</topic><topic>Male</topic><topic>Medical instruments</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitroglycerin</topic><topic>Nitroglycerin - pharmacology</topic><topic>Nitroprusside - pharmacology</topic><topic>Occlusion</topic><topic>Pharmacology</topic><topic>Plethysmography</topic><topic>Plethysmography - methods</topic><topic>Regional Blood Flow - drug effects</topic><topic>Sodium</topic><topic>Sodium nitroprusside</topic><topic>Ultrasound</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasodilation</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ranadive, Sushant M</creatorcontrib><creatorcontrib>Eugene, Andy R</creatorcontrib><creatorcontrib>Dillon, Gabrielle</creatorcontrib><creatorcontrib>Nicholson, Wayne T</creatorcontrib><creatorcontrib>Joyner, Michael J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranadive, Sushant M</au><au>Eugene, Andy R</au><au>Dillon, Gabrielle</au><au>Nicholson, Wayne T</au><au>Joyner, Michael J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>123</volume><issue>2</issue><spage>402</spage><epage>406</epage><pages>402-406</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>The vasodilatory mechanism of Nntroglycerin (NTG) is similar to sodium nitroprusside (SNP) in regard to action on guanosine 3'5'-monophosphate (cyclic GMP) via nitric oxide. However, it is unknown whether NTG can achieve the same magnitude of vasodilation in the forearm as SNP. Therefore, the purpose of the study was to evaluate the differences in forearm blood flow (FBF) and forearm vascular conductance (FVC) during escalating infusions of NTG vs. SNP at similar concentration doses and rates. We measured FBF using venous occlusion plethysmography (VOP) and Doppler ultrasound in eight young, healthy participants (mean age = 28 ± 2 yr) during four forearm volume (FAV)-specific doses (0.25, 0.5, 1, and 2 µg·100 ml FAV
·min
) of SNP and NTG infused via a brachial artery catheter. There was a significant difference in FVC of SNP vs. NTG only at the higher doses, as measured by VOP (14.9 ± 1.4 and 18.3 ± 1.5 vs. 11.6 ± 1.2 and 12.5 ± 1.2 ml/dl FAV
·min
·100 mmHg
). FVC as measured by Doppler ultrasound unadjusted for FAV was significantly different at the lowest and the higher two doses of SNP compared with NTG (202.1 ± 25.8, 329.4 ± 46.7, and 408 ± 63.5 vs. 142.9 ± 22.4, 217.2 ± 18.8, and 247.5 ± 18.2 ml·min
·100 mmHg
). SNP induces significantly higher vasodilatory actions compared with NTG. However, NTG is comparable in eliciting equivalent vasodilator effects to SNP during low concentration doses when measured by VOP. Importantly, for forearm pharmacology studies, NTG can elicit marked endothelium-independent forearm vasodilation.
We compared the vasodilatory capacities of NTG vs. SNP at similar concentration doses and rates into the forearm. Based on the results of the study, it may be feasible to use intra-arterial NTG as a measure of endothelial-independent vasodilator in research studies. However, NTG dosing may need to be higher if used as an endothelial-independent vasodilator due to significant differences in the vasodilatory effects during higher doses of SNP compared with NTG.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>28572495</pmid><doi>10.1152/japplphysiol.00167.2017</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Blood flow Brachial Artery - drug effects Brachial Artery - metabolism Conductance Cyclic GMP Doppler effect Drugs Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Forearm Forearm - blood supply Guanosine Humans Innovative Methodology Male Medical instruments Nitric oxide Nitric Oxide - metabolism Nitroglycerin Nitroglycerin - pharmacology Nitroprusside - pharmacology Occlusion Pharmacology Plethysmography Plethysmography - methods Regional Blood Flow - drug effects Sodium Sodium nitroprusside Ultrasound Vascular Resistance - drug effects Vasodilation Vasodilation - drug effects Vasodilator Agents - pharmacology |
| title | Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin |
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