Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications
Long non-coding RNAs(lnc RNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lnc RNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2017-08, Vol.23 (32), p.5860-5874 |
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| creator | Niu, Zhao-Shan Niu, Xiao-Jun Wang, Wen-Hong |
| description | Long non-coding RNAs(lnc RNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lnc RNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma(HCC). Certain lnc RNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lnc RNAs in tumors can contribute to a better understanding of the molecular mechanisms of HCC and may help in developing novel therapeutic targets. In this review, we summarize the recent progress regarding the functional roles of lnc RNAs in HCC and explore their clinical implications as diagnostic or prognostic biomarkers and molecular therapeutic targets for HCC. |
| doi_str_mv | 10.3748/wjg.v23.i32.5860 |
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Emerging evidence indicates that lnc RNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma(HCC). Certain lnc RNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lnc RNAs in tumors can contribute to a better understanding of the molecular mechanisms of HCC and may help in developing novel therapeutic targets. In this review, we summarize the recent progress regarding the functional roles of lnc RNAs in HCC and explore their clinical implications as diagnostic or prognostic biomarkers and molecular therapeutic targets for HCC.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v23.i32.5860</identifier><identifier>PMID: 28932078</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Antineoplastic Agents - therapeutic use ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - antagonists & inhibitors ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Carcinogenesis - genetics ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Disease Progression ; Early Detection of Cancer - methods ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms - diagnosis ; Liver Neoplasms - drug therapy ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Molecular Targeted Therapy - methods ; Prognosis ; Review ; RNA, Long Noncoding - analysis ; RNA, Long Noncoding - antagonists & inhibitors ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism</subject><ispartof>World journal of gastroenterology : WJG, 2017-08, Vol.23 (32), p.5860-5874</ispartof><rights>The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-913d86e325118463d6571c6b26e53a64b52d4dae386a4df32f226cd604f9a4b03</citedby><cites>FETCH-LOGICAL-c440t-913d86e325118463d6571c6b26e53a64b52d4dae386a4df32f226cd604f9a4b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583571/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583571/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28932078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niu, Zhao-Shan</creatorcontrib><creatorcontrib>Niu, Xiao-Jun</creatorcontrib><creatorcontrib>Wang, Wen-Hong</creatorcontrib><title>Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>Long non-coding RNAs(lnc RNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lnc RNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma(HCC). Certain lnc RNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lnc RNAs in tumors can contribute to a better understanding of the molecular mechanisms of HCC and may help in developing novel therapeutic targets. In this review, we summarize the recent progress regarding the functional roles of lnc RNAs in HCC and explore their clinical implications as diagnostic or prognostic biomarkers and molecular therapeutic targets for HCC.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - antagonists & inhibitors</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Disease Progression</subject><subject>Early Detection of Cancer - methods</subject><subject>Epigenesis, Genetic</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Molecular Targeted Therapy - methods</subject><subject>Prognosis</subject><subject>Review</subject><subject>RNA, Long Noncoding - analysis</subject><subject>RNA, Long Noncoding - antagonists & inhibitors</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1vGyEQxVHVqHGT3nuq9tjLusAAy_ZQKYr6JVlNFCWnHhAG1iZiwYF1ovz3xYljpVwYDW_ePPRD6CPBc-iY_PJwu5rfU5h7oHMuBX6DZpSSvqWS4bdoRjDu2h5od4zel3KLMQXg9B06prJ2cSdn6O8ixVUTU2xNsr6WV3_OSuNjs3YbPSXjQtgGnRujs_Exjfprc5kmFyevQ5NTcKXR0TYm-OhNbflxE2ox-RTLKToadCjuw_4-QTc_vl-f_2oXFz9_n58tWsMYntqegJXCAeWESCbACt4RI5ZUOA5asCWnllntQArN7AB0oFQYKzAbes2WGE7Qt2ffzXY5OmtquqyD2mQ_6vyokvbq_5fo12qV7hXnEuquavB5b5DT3daVSY2-7L6uo0vbokjPCHS4BqxS_Cw1OZWS3XBYQ7DaMVGViapMVGWidkzqyKfX8Q4DLxCqAPae6wrjrlI4aHosd6fnmEnWc87JUyU5wD_IpZlk</recordid><startdate>20170828</startdate><enddate>20170828</enddate><creator>Niu, Zhao-Shan</creator><creator>Niu, Xiao-Jun</creator><creator>Wang, Wen-Hong</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170828</creationdate><title>Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications</title><author>Niu, Zhao-Shan ; Niu, Xiao-Jun ; Wang, Wen-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-913d86e325118463d6571c6b26e53a64b52d4dae386a4df32f226cd604f9a4b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - antagonists & inhibitors</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Disease Progression</topic><topic>Early Detection of Cancer - methods</topic><topic>Epigenesis, Genetic</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Molecular Targeted Therapy - methods</topic><topic>Prognosis</topic><topic>Review</topic><topic>RNA, Long Noncoding - analysis</topic><topic>RNA, Long Noncoding - antagonists & inhibitors</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Niu, Zhao-Shan</creatorcontrib><creatorcontrib>Niu, Xiao-Jun</creatorcontrib><creatorcontrib>Wang, Wen-Hong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niu, Zhao-Shan</au><au>Niu, Xiao-Jun</au><au>Wang, Wen-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2017-08-28</date><risdate>2017</risdate><volume>23</volume><issue>32</issue><spage>5860</spage><epage>5874</epage><pages>5860-5874</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Long non-coding RNAs(lnc RNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lnc RNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma(HCC). Certain lnc RNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lnc RNAs in tumors can contribute to a better understanding of the molecular mechanisms of HCC and may help in developing novel therapeutic targets. In this review, we summarize the recent progress regarding the functional roles of lnc RNAs in HCC and explore their clinical implications as diagnostic or prognostic biomarkers and molecular therapeutic targets for HCC.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>28932078</pmid><doi>10.3748/wjg.v23.i32.5860</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - therapeutic use Biomarkers, Tumor - analysis Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinogenesis - genetics Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Disease Progression Early Detection of Cancer - methods Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Liver Neoplasms - diagnosis Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - mortality Molecular Targeted Therapy - methods Prognosis Review RNA, Long Noncoding - analysis RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism |
| title | Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications |
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