Structural origins of clustered protocadherin-mediated neuronal barcoding
Clustered protocadherins mediate neuronal self-recognition and non-self discrimination—neuronal “barcoding”—which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compel...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2017-09, Vol.69 (C), p.140-150 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Rubinstein, Rotem Goodman, Kerry Marie Maniatis, Tom Shapiro, Lawrence Honig, Barry |
| description | Clustered protocadherins mediate neuronal self-recognition and non-self discrimination—neuronal “barcoding”—which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular model for the barcoding mechanism. Protocadherin isoforms assemble into promiscuous cis-dimeric recognition units and mediate cell–cell recognition through homophilic trans-interactions. Each recognition unit is composed of two arms extending from the membrane proximal EC6 domains. A cis-dimeric recognition unit with each arm coding adhesive trans homophilic specificity can generate a zipper-like assembly that in turn suggests a chain termination mechanism for self-vs-non-self-discrimination among vertebrate neurons. |
| doi_str_mv | 10.1016/j.semcdb.2017.07.023 |
| format | Article |
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(ANL), Argonne, IL (United States). Advanced Photon Source (APS)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in cell & developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rubinstein, Rotem</au><au>Goodman, Kerry Marie</au><au>Maniatis, Tom</au><au>Shapiro, Lawrence</au><au>Honig, Barry</au><aucorp>Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural origins of clustered protocadherin-mediated neuronal barcoding</atitle><jtitle>Seminars in cell & developmental biology</jtitle><addtitle>Semin Cell Dev Biol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>69</volume><issue>C</issue><spage>140</spage><epage>150</epage><pages>140-150</pages><issn>1084-9521</issn><eissn>1096-3634</eissn><abstract>Clustered protocadherins mediate neuronal self-recognition and non-self discrimination—neuronal “barcoding”—which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular model for the barcoding mechanism. Protocadherin isoforms assemble into promiscuous cis-dimeric recognition units and mediate cell–cell recognition through homophilic trans-interactions. 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| subjects | Animals Cadherins - chemistry Cadherins - metabolism Cell-cell recognition Clustered protocadherins Crystal structure Humans Models, Molecular Neuronal self-avoidance Neurons - metabolism Phylogeny Protein interaction specificity Protein Multimerization Structure-Activity Relationship |
| title | Structural origins of clustered protocadherin-mediated neuronal barcoding |
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