NADPH oxidase inhibitor, diphenyleneiodonium prevents necroptosis in HK-2 cells

The aim of the present study was to investigate the protective effect of the NADPH oxidase inhibitor, diphenyleneiodonium (DPI) against necroptosis in renal tubular epithelial cells. A necroptosis model of HK-2 cells was established using tumor necrosis factor-α, benzyloxycarbonyl-Val-Ala-Asp-fluoro...

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Veröffentlicht in:	Biomedical reports 2017-09, Vol.7 (3), p.226-230
Hauptverfasser:	Dong, Wei, Li, Zhilian, Chen, Yuanhan, Zhang, Li, Ye, Zhiming, Liang, Huaban, Li, Ruizhao, Xu, Lixia, Zhang, Bin, Liu, Shuangxin, Wang, Weidong, Li, Chunling, Luo, Jialun, Shi, Wei, Liang, Xinling
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Analysis Antimycin A Apoptosis Biotechnology Cell death Cytometry diphenyleneiodonium Epithelial cells Flow cytometry Immunoglobulins Inhibitors Ischemia Kidneys Kinases MAP kinase NAD(P)H oxidase Necroptosis Oxidase Oxidases Phosphorylation Propidium iodide Protein kinase Proteins Reactive oxygen species renal tubular epithelial cell Studies Tumor necrosis factor Tumor necrosis factor-TNF Tumor necrosis factor-α
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