PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Through an shRNA screen, we identified the protein arginine methyltransferase Prmt1 as a vulnerable intervention point in murine p53/Rb-null osteosarcomas, the human counterpart of which lacks effective therapeutic options. Depletion of Prmt1 in p53-deficient cells impaired tumor initiation and main...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-09, Vol.77 (17), p.4613-4625
Hauptverfasser:	Hsu, Jessie Hao-Ru, Hubbell-Engler, Benjamin, Adelmant, Guillaume, Huang, Jialiang, Joyce, Cailin E, Vazquez, Francisca, Weir, Barbara A, Montgomery, Philip, Tsherniak, Aviad, Giacomelli, Andrew O, Perry, Jennifer A, Trowbridge, Jennifer, Fujiwara, Yuko, Cowley, Glenn S, Xie, Huafeng, Kim, Woojin, Novina, Carl D, Hahn, William C, Marto, Jarrod A, Orkin, Stuart H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Bone cancer Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer Cellular stress response DNA Methylation Gene Expression Regulation, Neoplastic Initiation complex Methylation Mice Mice, Knockout Null cells Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology p53 Protein Protein arginine methyltransferase Protein Biosynthesis Protein-Arginine N-Methyltransferases - physiology Proteomics Retinoblastoma Protein - physiology Sarcoma Translation Translation initiation Tumor Cells, Cultured Tumor Suppressor Protein p53 - physiology Xenograft Model Antitumor Assays
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