Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction

Osteosarcoma is an aggressive malignant bone tumor that causes bone destruction. Although tumor‐specific replicating oncolytic adenovirus OBP‐301 induces an antitumor effect in an osteosarcoma tumor, it cannot prevent bone destruction. Zoledronic acid (ZOL) is a clinically available agent that inhib...

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Veröffentlicht in:	Cancer science 2017-09, Vol.108 (9), p.1870-1880
Hauptverfasser:	Yamakawa, Yasuaki, Tazawa, Hiroshi, Hasei, Joe, Osaki, Shuhei, Omori, Toshinori, Sugiu, Kazuhisa, Komatsubara, Tadashi, Uotani, Kouji, Fujiwara, Tomohiro, Yoshida, Aki, Kunisada, Toshiyuki, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, Fujiwara, Toshiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses Animals Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Bone cancer bone destruction Bone growth Bone Neoplasms - pathology Bone Neoplasms - therapy Bone tumors Cancer therapies Cell cycle Cell Differentiation Cell Line, Tumor Cell Proliferation Chemotherapy Coculture Techniques Combined Modality Therapy Cytotoxicity Diphosphonates - pharmacology Drug Screening Assays, Antitumor Female Humans Imidazoles - pharmacology Infections Mcl-1 protein Medical prognosis Metastasis Mice Mice, Nude Oncolysis Oncolytic Virotherapy Original Osteoclasts - drug effects Osteoclasts - physiology Osteosarcoma Osteosarcoma - pathology Osteosarcoma - therapy Osteosarcoma cells Prostate cancer Protein expression Proteins RANK Ligand - pharmacology RAW 264.7 Cells Telomerase Tumor Burden Tumors Xenograft Model Antitumor Assays Xenografts Zoledronic Acid
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