Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice
Tissue repair is fundamental to our survival as tissues are challenged by recurrent damage. During mammalian skin repair, cells respond by migrating and proliferating to close the wound. However, the coordination of cellular repair behaviours and their effects on homeostatic functions in a live mamm...
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| Veröffentlicht in: | Nature cell biology 2017-03, Vol.19 (3), p.155-163 |
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| creator | Park, Sangbum Gonzalez, David G. Guirao, Boris Boucher, Jonathan D. Cockburn, Katie Marsh, Edward D. Mesa, Kailin R. Brown, Samara Rompolas, Panteleimon Haberman, Ann M. Bellaïche, Yohanns Greco, Valentina |
| description | Tissue repair is fundamental to our survival as tissues are challenged by recurrent damage. During mammalian skin repair, cells respond by migrating and proliferating to close the wound. However, the coordination of cellular repair behaviours and their effects on homeostatic functions in a live mammal remains unclear. Here we capture the spatiotemporal dynamics of individual epithelial behaviours by imaging wound re-epithelialization in live mice. Differentiated cells migrate while the rate of differentiation changes depending on local rate of migration and tissue architecture. Cells depart from a highly proliferative zone by directionally dividing towards the wound while collectively migrating. This regional coexistence of proliferation and migration leads to local expansion and elongation of the repairing epithelium. Finally, proliferation functions to pattern and restrict the recruitment of undamaged cells. This study elucidates the interplay of cellular repair behaviours and consequent changes in homeostatic behaviours that support tissue-scale organization of wound re-epithelialization.
Park
et al.
study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation. |
| doi_str_mv | 10.1038/ncb3472 |
| format | Article |
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Park
et al.
study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.</description><identifier>ISSN: 1465-7392</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/ncb3472</identifier><identifier>PMID: 28248302</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/334/1874/345 ; 631/1647/328 ; 631/532/489 ; Animal tissues ; Behavior ; Biology ; Cancer Research ; Cell Biology ; Cell division ; Cell regulation ; Developmental Biology ; Epithelium ; Growth ; Health aspects ; Innovations ; Life Sciences ; Mammals ; Medicine ; Stem Cells ; Tissue engineering ; Wound healing</subject><ispartof>Nature cell biology, 2017-03, Vol.19 (3), p.155-163</ispartof><rights>Springer Nature Limited 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2017</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-733052581fcdcbd7581738619ec4282f9a8142c1dbbf5d1fcfd3ec4b8053a6133</citedby><cites>FETCH-LOGICAL-c598t-733052581fcdcbd7581738619ec4282f9a8142c1dbbf5d1fcfd3ec4b8053a6133</cites><orcidid>0000-0001-6168-6606</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28248302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04790589$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Sangbum</creatorcontrib><creatorcontrib>Gonzalez, David G.</creatorcontrib><creatorcontrib>Guirao, Boris</creatorcontrib><creatorcontrib>Boucher, Jonathan D.</creatorcontrib><creatorcontrib>Cockburn, Katie</creatorcontrib><creatorcontrib>Marsh, Edward D.</creatorcontrib><creatorcontrib>Mesa, Kailin R.</creatorcontrib><creatorcontrib>Brown, Samara</creatorcontrib><creatorcontrib>Rompolas, Panteleimon</creatorcontrib><creatorcontrib>Haberman, Ann M.</creatorcontrib><creatorcontrib>Bellaïche, Yohanns</creatorcontrib><creatorcontrib>Greco, Valentina</creatorcontrib><title>Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice</title><title>Nature cell biology</title><addtitle>Nat Cell Biol</addtitle><addtitle>Nat Cell Biol</addtitle><description>Tissue repair is fundamental to our survival as tissues are challenged by recurrent damage. During mammalian skin repair, cells respond by migrating and proliferating to close the wound. However, the coordination of cellular repair behaviours and their effects on homeostatic functions in a live mammal remains unclear. Here we capture the spatiotemporal dynamics of individual epithelial behaviours by imaging wound re-epithelialization in live mice. Differentiated cells migrate while the rate of differentiation changes depending on local rate of migration and tissue architecture. Cells depart from a highly proliferative zone by directionally dividing towards the wound while collectively migrating. This regional coexistence of proliferation and migration leads to local expansion and elongation of the repairing epithelium. Finally, proliferation functions to pattern and restrict the recruitment of undamaged cells. This study elucidates the interplay of cellular repair behaviours and consequent changes in homeostatic behaviours that support tissue-scale organization of wound re-epithelialization.
Park
et al.
study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.</description><subject>631/136/334/1874/345</subject><subject>631/1647/328</subject><subject>631/532/489</subject><subject>Animal tissues</subject><subject>Behavior</subject><subject>Biology</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cell division</subject><subject>Cell regulation</subject><subject>Developmental Biology</subject><subject>Epithelium</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Innovations</subject><subject>Life Sciences</subject><subject>Mammals</subject><subject>Medicine</subject><subject>Stem Cells</subject><subject>Tissue engineering</subject><subject>Wound 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Sangbum</au><au>Gonzalez, David G.</au><au>Guirao, Boris</au><au>Boucher, Jonathan D.</au><au>Cockburn, Katie</au><au>Marsh, Edward D.</au><au>Mesa, Kailin R.</au><au>Brown, Samara</au><au>Rompolas, Panteleimon</au><au>Haberman, Ann M.</au><au>Bellaïche, Yohanns</au><au>Greco, Valentina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>19</volume><issue>3</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>1465-7392</issn><eissn>1476-4679</eissn><abstract>Tissue repair is fundamental to our survival as tissues are challenged by recurrent damage. During mammalian skin repair, cells respond by migrating and proliferating to close the wound. However, the coordination of cellular repair behaviours and their effects on homeostatic functions in a live mammal remains unclear. Here we capture the spatiotemporal dynamics of individual epithelial behaviours by imaging wound re-epithelialization in live mice. Differentiated cells migrate while the rate of differentiation changes depending on local rate of migration and tissue architecture. Cells depart from a highly proliferative zone by directionally dividing towards the wound while collectively migrating. This regional coexistence of proliferation and migration leads to local expansion and elongation of the repairing epithelium. Finally, proliferation functions to pattern and restrict the recruitment of undamaged cells. This study elucidates the interplay of cellular repair behaviours and consequent changes in homeostatic behaviours that support tissue-scale organization of wound re-epithelialization.
Park
et al.
study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28248302</pmid><doi>10.1038/ncb3472</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6168-6606</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136/334/1874/345 631/1647/328 631/532/489 Animal tissues Behavior Biology Cancer Research Cell Biology Cell division Cell regulation Developmental Biology Epithelium Growth Health aspects Innovations Life Sciences Mammals Medicine Stem Cells Tissue engineering Wound healing |
| title | Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice |
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