The association of single nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes

Abstract Background Oxytocin is a potent uterotonic agent that is widely used for induction and augmentation of labor. Oxytocin has a narrow therapeutic index and the optimal dosing for any individual woman varies widely. Objective The objective of this study was to determine if genetic variation in...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2017-09, Vol.217 (3), p.367.e1-367.e9
Hauptverfasser:	Grotegut, Chad A., MD MHS, Ngan, Emily, Ms, Garrett, Melanie E., Ms, Miranda, Marie Lynn, PhD, Ashley-Koch, Allison E., PhD, Swamy, Geeta K., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult desensitization Dose-Response Relationship, Drug Female G protein–coupled receptor G protein–coupled receptor kinase 6 G-Protein-Coupled Receptor Kinases - genetics Genotype GRK6 Humans induction of labor labor Labor, Induced Obstetrics and Gynecology Oxytocics - administration & dosage oxytocin Oxytocin - administration & dosage oxytocin receptor Pharmacogenomic Testing Polymorphism, Single Nucleotide Pregnancy Prospective Studies Receptors, Oxytocin - genetics single-nucleotide polymorphism Time Factors β-arrestin
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