Assembly and analysis of 100 full MHC haplotypes from the Danish population

Genes in the major histocompatibility complex (MHC, also known as HLA) play a critical role in the immune response and variation within the extended 4-Mb region shows association with major risks of many diseases. Yet, deciphering the underlying causes of these associations is difficult because the...

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Veröffentlicht in:	Genome research 2017-09, Vol.27 (9), p.1597-1607
Hauptverfasser:	Jensen, Jacob M, Villesen, Palle, Friborg, Rune M, Mailund, Thomas, Besenbacher, Søren, Schierup, Mikkel H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Chromosome Mapping Denmark Genetic Variation - genetics Genetics, Population Haplotypes - genetics Humans Linkage Disequilibrium - genetics Major Histocompatibility Complex - genetics Polymorphism, Single Nucleotide - genetics Resource
Online-Zugang:	Volltext
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