HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets

has diverse functional roles in differentiation and development. We identify and characterize properties of regions bound by HOXA1 on a genome-wide basis in differentiating mouse ES cells. HOXA1-bound regions are enriched for clusters of consensus binding motifs for HOX, PBX, and MEIS, and many disp...

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Veröffentlicht in:	Genome research 2017-09, Vol.27 (9), p.1501-1512
Hauptverfasser:	De Kumar, Bony, Parker, Hugo J, Paulson, Ariel, Parrish, Mark E, Pushel, Irina, Singh, Narendra Pratap, Zhang, Ying, Slaughter, Brian D, Unruh, Jay R, Florens, Laurence, Zeitlinger, Julia, Krumlauf, Robb
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin - genetics Genome - genetics Homeodomain Proteins - genetics Mice Mouse Embryonic Stem Cells Protein Binding - genetics Protein Interaction Maps - genetics Proteomics Repressor Proteins - genetics Transcription Factors - genetics Transcription, Genetic
Online-Zugang:	Volltext
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