Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy
Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may...
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| Veröffentlicht in: | International journal of environmental research and public health 2017-08, Vol.14 (8), p.855 |
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| container_title | International journal of environmental research and public health |
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| creator | Miconi, Francesco Savarese, Emanuela Miconi, Giovanni Cabiati, Gabriele Rapaccini, Valentina Principi, Nicola Esposito, Susanna |
| description | Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD.
A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced.
This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD. |
| doi_str_mv | 10.3390/ijerph14080855 |
| format | Article |
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A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced.
This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph14080855</identifier><identifier>PMID: 28758924</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abdomen ; Aberration ; Acetic acid ; Addison Disease - drug therapy ; Adrenal glands ; Autoimmune diseases ; Biopsy ; Blood ; Case Report ; Celiac disease ; Celiac Disease - diet therapy ; Child ; Children ; Cortisol ; Diabetes ; Diet, Gluten-Free ; Disease ; Endocrine disorders ; Gluten ; Humans ; Hydrocortisone - administration & dosage ; Hydrocortisone - therapeutic use ; Immune response ; Immune system ; Immunoglobulins ; Laboratories ; Male ; Pediatrics ; Signs and symptoms ; Small intestine ; Thyroid gland</subject><ispartof>International journal of environmental research and public health, 2017-08, Vol.14 (8), p.855</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-9d1255e2623341a7f0b5ff379028deb1f84daf71a5508501621167ddb02b1473</citedby><cites>FETCH-LOGICAL-c385t-9d1255e2623341a7f0b5ff379028deb1f84daf71a5508501621167ddb02b1473</cites><orcidid>0000-0003-4103-2837</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580559/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580559/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28758924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miconi, Francesco</creatorcontrib><creatorcontrib>Savarese, Emanuela</creatorcontrib><creatorcontrib>Miconi, Giovanni</creatorcontrib><creatorcontrib>Cabiati, Gabriele</creatorcontrib><creatorcontrib>Rapaccini, Valentina</creatorcontrib><creatorcontrib>Principi, Nicola</creatorcontrib><creatorcontrib>Esposito, Susanna</creatorcontrib><title>Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD.
A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced.
This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD.</description><subject>Abdomen</subject><subject>Aberration</subject><subject>Acetic acid</subject><subject>Addison Disease - drug therapy</subject><subject>Adrenal glands</subject><subject>Autoimmune diseases</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Case Report</subject><subject>Celiac disease</subject><subject>Celiac Disease - diet therapy</subject><subject>Child</subject><subject>Children</subject><subject>Cortisol</subject><subject>Diabetes</subject><subject>Diet, Gluten-Free</subject><subject>Disease</subject><subject>Endocrine disorders</subject><subject>Gluten</subject><subject>Humans</subject><subject>Hydrocortisone - administration & dosage</subject><subject>Hydrocortisone - therapeutic use</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunoglobulins</subject><subject>Laboratories</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Signs and symptoms</subject><subject>Small intestine</subject><subject>Thyroid gland</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUE1PAjEQbYxGEL16NE08eFrsx3a3vZggfoeECx48NV3aSsnSYrtrwr93DUjwNJOZN--9eQBcYjSkVKBbtzRxvcA54ogzdgT6uChQlhcIHx_0PXCW0hIhyvNCnIIe4SXjguR98Pbu29SqGk59Mg0MFo5N7dQcPrhkVDJQeQ1HWrsU_E3aT52HCmKSfRgVs2mt4X3YnIMTq-pkLnZ1AGZPj7PxSzaZPr-OR5NsTjlrMqExYcyQglCaY1VaVDFraSkQ4dpU2PJcK1tixVj3EsIFwbgota4QqXBe0gG429Ku22pl9Nz4JqparqNbqbiRQTn5f-PdQn6Gb8kYR4yJjuB6RxDDV2tSI5ehjb6zLLGgQlDCBO5Qwy1qHkNK0di9AkbyN3r5P_ru4OrQ1x7-lzX9AeItfjE</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Miconi, Francesco</creator><creator>Savarese, Emanuela</creator><creator>Miconi, Giovanni</creator><creator>Cabiati, Gabriele</creator><creator>Rapaccini, Valentina</creator><creator>Principi, Nicola</creator><creator>Esposito, Susanna</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4103-2837</orcidid></search><sort><creationdate>20170801</creationdate><title>Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy</title><author>Miconi, Francesco ; Savarese, Emanuela ; Miconi, Giovanni ; Cabiati, Gabriele ; Rapaccini, Valentina ; Principi, Nicola ; Esposito, Susanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-9d1255e2623341a7f0b5ff379028deb1f84daf71a5508501621167ddb02b1473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdomen</topic><topic>Aberration</topic><topic>Acetic acid</topic><topic>Addison Disease - drug therapy</topic><topic>Adrenal glands</topic><topic>Autoimmune diseases</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Case Report</topic><topic>Celiac disease</topic><topic>Celiac Disease - diet therapy</topic><topic>Child</topic><topic>Children</topic><topic>Cortisol</topic><topic>Diabetes</topic><topic>Diet, Gluten-Free</topic><topic>Disease</topic><topic>Endocrine disorders</topic><topic>Gluten</topic><topic>Humans</topic><topic>Hydrocortisone - administration & dosage</topic><topic>Hydrocortisone - therapeutic use</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunoglobulins</topic><topic>Laboratories</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Signs and symptoms</topic><topic>Small intestine</topic><topic>Thyroid gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miconi, Francesco</creatorcontrib><creatorcontrib>Savarese, Emanuela</creatorcontrib><creatorcontrib>Miconi, Giovanni</creatorcontrib><creatorcontrib>Cabiati, Gabriele</creatorcontrib><creatorcontrib>Rapaccini, Valentina</creatorcontrib><creatorcontrib>Principi, Nicola</creatorcontrib><creatorcontrib>Esposito, Susanna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miconi, Francesco</au><au>Savarese, Emanuela</au><au>Miconi, Giovanni</au><au>Cabiati, Gabriele</au><au>Rapaccini, Valentina</au><au>Principi, Nicola</au><au>Esposito, Susanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>14</volume><issue>8</issue><spage>855</spage><pages>855-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD.
A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced.
This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28758924</pmid><doi>10.3390/ijerph14080855</doi><orcidid>https://orcid.org/0000-0003-4103-2837</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Aberration Acetic acid Addison Disease - drug therapy Adrenal glands Autoimmune diseases Biopsy Blood Case Report Celiac disease Celiac Disease - diet therapy Child Children Cortisol Diabetes Diet, Gluten-Free Disease Endocrine disorders Gluten Humans Hydrocortisone - administration & dosage Hydrocortisone - therapeutic use Immune response Immune system Immunoglobulins Laboratories Male Pediatrics Signs and symptoms Small intestine Thyroid gland |
| title | Unusual Onset of Celiac Disease and Addison's Disease in a 12-Year-Old Boy |
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