Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line
The Perla Negra cultivar is a recently-obtained biological material whose progenitors are var. and var. the latter of which has been reported to have antiproliferative activity against the HeLa P-388 and L-929 cancer cell lines. The present study aimed to determine if the methanolic extract of the f...
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| Veröffentlicht in: | Nutrients 2017-07, Vol.9 (8), p.798 |
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| creator | Salazar-Aguilar, Sandra Ruiz-Posadas, Lucero Del Mar Cadena-Iñiguez, Jorge Soto-Hernández, Marcos Santiago-Osorio, Edelmiro Aguiñiga-Sánchez, Itzen Rivera-Martínez, Ana Rocío Aguirre-Medina, Juan Francisco |
| description | The
Perla Negra cultivar is a recently-obtained biological material whose progenitors are
var.
and
var.
the latter of which has been reported to have antiproliferative activity against the HeLa P-388 and L-929 cancer cell lines. The present study aimed to determine if the methanolic extract of the fruit of the Perla Negra cultivar had the same biological activity. The methanolic extract was phytochemically characterized by thin layer chromatography (TLC) and column chromatography (CC), identifying the terpenes and flavonoids. The compounds identified via high performance liquid chromatography (HPLC) were Cucurbitacins B, D, E, and I for the terpene fractions, and Rutin, Phlorizidin, Myricetin, Quercetin, Naringenin, Phloretin, Apigenin, and Galangin for the flavonoid fractions). Biological activity was evaluated with different concentrations of the methanolic extract in the HeLa cell line and normal lymphocytes. The methanolic extract inhibited the proliferation of HeLa cells (IC
1.85 µg·mL
), but the lymphocytes were affected by the extract (IC
30.04 µg·mL
). Some fractions, and the pool of all of them, showed inhibition higher than 80% at a concentration of 2.11 µg·mL
. Therefore, the biological effect shown by the methanolic extract of the Perla Negra has some specificity in inhibiting tumor cells and not normal cells; an unusual feature among molecules investigated as potential biomedical agents. |
| doi_str_mv | 10.3390/nu9080798 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5579592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1924886323</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-d2c0331a96a9f75fd50269694abac8b34c2dfa9ccebb4158ae47b55d027c9e653</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhS0EolXpgT-ALHFpJbY4dmzHF6QqKl3QCpAKZ2viTFhXibN14l3Br69XLavCBV9sPX9-88ZDyOuCXQhh2PuQDKuYNtUzcsyZ5gulSvH8yfmInE7TLdsvzbQSL8kRr7TU0ohjsrtBt_ZpoNimHunZZ3B3F-f0Zgdx_v2OAv2CO1qnfvZbiHTn5zW9DLPfxLH3HUbIOtJv44xZhJ76kJ8s0wCB1hi33mWthuAw0iWuIIt9T1c-4CvyooN-wtPH_YT8-Hj1vV4uVl-vP9WXq4UrhZoXLXdMiAKMAtNp2bWScWWUKaEBVzWidLztwDiHTVMWsgIsdSNly7h2BpUUJ-TDg-8mNQO2LueM0NtN9APEX3YEb_--CX5tf45bK6U20vBscPZoEMe7hNNsBz-53AYEHNNkOa9yHJEL_hctDC-rSgkuMvr2H_R2TDHkn8hUmc24UXvq_IFycZymiN0hd8Hsfvj2MPzMvnna6IH8M2pxDzqVqWM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1940272963</pqid></control><display><type>article</type><title>Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Salazar-Aguilar, Sandra ; Ruiz-Posadas, Lucero Del Mar ; Cadena-Iñiguez, Jorge ; Soto-Hernández, Marcos ; Santiago-Osorio, Edelmiro ; Aguiñiga-Sánchez, Itzen ; Rivera-Martínez, Ana Rocío ; Aguirre-Medina, Juan Francisco</creator><creatorcontrib>Salazar-Aguilar, Sandra ; Ruiz-Posadas, Lucero Del Mar ; Cadena-Iñiguez, Jorge ; Soto-Hernández, Marcos ; Santiago-Osorio, Edelmiro ; Aguiñiga-Sánchez, Itzen ; Rivera-Martínez, Ana Rocío ; Aguirre-Medina, Juan Francisco</creatorcontrib><description>The
Perla Negra cultivar is a recently-obtained biological material whose progenitors are
var.
and
var.
the latter of which has been reported to have antiproliferative activity against the HeLa P-388 and L-929 cancer cell lines. The present study aimed to determine if the methanolic extract of the fruit of the Perla Negra cultivar had the same biological activity. The methanolic extract was phytochemically characterized by thin layer chromatography (TLC) and column chromatography (CC), identifying the terpenes and flavonoids. The compounds identified via high performance liquid chromatography (HPLC) were Cucurbitacins B, D, E, and I for the terpene fractions, and Rutin, Phlorizidin, Myricetin, Quercetin, Naringenin, Phloretin, Apigenin, and Galangin for the flavonoid fractions). Biological activity was evaluated with different concentrations of the methanolic extract in the HeLa cell line and normal lymphocytes. The methanolic extract inhibited the proliferation of HeLa cells (IC
1.85 µg·mL
), but the lymphocytes were affected by the extract (IC
30.04 µg·mL
). Some fractions, and the pool of all of them, showed inhibition higher than 80% at a concentration of 2.11 µg·mL
. Therefore, the biological effect shown by the methanolic extract of the Perla Negra has some specificity in inhibiting tumor cells and not normal cells; an unusual feature among molecules investigated as potential biomedical agents.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9080798</identifier><identifier>PMID: 28757593</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antineoplastic Agents, Phytogenic - pharmacology ; apigenin ; Apigenin - pharmacology ; bioactive properties ; Biological activity ; Biological effects ; Biological materials ; Biomedical materials ; Cell proliferation ; Cell Proliferation - drug effects ; Cervical cancer ; Cervix ; Chromatography ; Column chromatography ; Cucurbitaceae - chemistry ; cucurbitacins ; Cucurbitacins - pharmacology ; cultivars ; Female ; Flavanones - pharmacology ; Flavonoids ; Flavonoids - pharmacology ; Fruit - chemistry ; fruits ; HeLa Cells ; High performance liquid chromatography ; human cell lines ; Humans ; Inhibitory Concentration 50 ; Liquid chromatography ; Lymphocytes ; myricetin ; Naringenin ; neoplasm cells ; new variety ; Perla ; Phloretin - pharmacology ; Phytochemicals - pharmacology ; Plant Extracts - pharmacology ; Quercetin ; Quercetin - pharmacology ; Rutin ; Rutin - pharmacology ; Sechium edule ; Thin layer chromatography ; Tumor cell lines ; Tumor cells ; uterine cervical neoplasms ; Uterine Cervical Neoplasms - drug therapy</subject><ispartof>Nutrients, 2017-07, Vol.9 (8), p.798</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-d2c0331a96a9f75fd50269694abac8b34c2dfa9ccebb4158ae47b55d027c9e653</citedby><cites>FETCH-LOGICAL-c436t-d2c0331a96a9f75fd50269694abac8b34c2dfa9ccebb4158ae47b55d027c9e653</cites><orcidid>0000-0002-8269-7854 ; 0000-0001-8577-7991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579592/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579592/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28757593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salazar-Aguilar, Sandra</creatorcontrib><creatorcontrib>Ruiz-Posadas, Lucero Del Mar</creatorcontrib><creatorcontrib>Cadena-Iñiguez, Jorge</creatorcontrib><creatorcontrib>Soto-Hernández, Marcos</creatorcontrib><creatorcontrib>Santiago-Osorio, Edelmiro</creatorcontrib><creatorcontrib>Aguiñiga-Sánchez, Itzen</creatorcontrib><creatorcontrib>Rivera-Martínez, Ana Rocío</creatorcontrib><creatorcontrib>Aguirre-Medina, Juan Francisco</creatorcontrib><title>Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The
Perla Negra cultivar is a recently-obtained biological material whose progenitors are
var.
and
var.
the latter of which has been reported to have antiproliferative activity against the HeLa P-388 and L-929 cancer cell lines. The present study aimed to determine if the methanolic extract of the fruit of the Perla Negra cultivar had the same biological activity. The methanolic extract was phytochemically characterized by thin layer chromatography (TLC) and column chromatography (CC), identifying the terpenes and flavonoids. The compounds identified via high performance liquid chromatography (HPLC) were Cucurbitacins B, D, E, and I for the terpene fractions, and Rutin, Phlorizidin, Myricetin, Quercetin, Naringenin, Phloretin, Apigenin, and Galangin for the flavonoid fractions). Biological activity was evaluated with different concentrations of the methanolic extract in the HeLa cell line and normal lymphocytes. The methanolic extract inhibited the proliferation of HeLa cells (IC
1.85 µg·mL
), but the lymphocytes were affected by the extract (IC
30.04 µg·mL
). Some fractions, and the pool of all of them, showed inhibition higher than 80% at a concentration of 2.11 µg·mL
. Therefore, the biological effect shown by the methanolic extract of the Perla Negra has some specificity in inhibiting tumor cells and not normal cells; an unusual feature among molecules investigated as potential biomedical agents.</description><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>apigenin</subject><subject>Apigenin - pharmacology</subject><subject>bioactive properties</subject><subject>Biological activity</subject><subject>Biological effects</subject><subject>Biological materials</subject><subject>Biomedical materials</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Chromatography</subject><subject>Column chromatography</subject><subject>Cucurbitaceae - chemistry</subject><subject>cucurbitacins</subject><subject>Cucurbitacins - pharmacology</subject><subject>cultivars</subject><subject>Female</subject><subject>Flavanones - pharmacology</subject><subject>Flavonoids</subject><subject>Flavonoids - pharmacology</subject><subject>Fruit - chemistry</subject><subject>fruits</subject><subject>HeLa Cells</subject><subject>High performance liquid chromatography</subject><subject>human cell lines</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Liquid chromatography</subject><subject>Lymphocytes</subject><subject>myricetin</subject><subject>Naringenin</subject><subject>neoplasm cells</subject><subject>new variety</subject><subject>Perla</subject><subject>Phloretin - pharmacology</subject><subject>Phytochemicals - pharmacology</subject><subject>Plant Extracts - pharmacology</subject><subject>Quercetin</subject><subject>Quercetin - pharmacology</subject><subject>Rutin</subject><subject>Rutin - pharmacology</subject><subject>Sechium edule</subject><subject>Thin layer chromatography</subject><subject>Tumor cell lines</subject><subject>Tumor cells</subject><subject>uterine cervical neoplasms</subject><subject>Uterine Cervical Neoplasms - drug therapy</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUFv1DAQhS0EolXpgT-ALHFpJbY4dmzHF6QqKl3QCpAKZ2viTFhXibN14l3Br69XLavCBV9sPX9-88ZDyOuCXQhh2PuQDKuYNtUzcsyZ5gulSvH8yfmInE7TLdsvzbQSL8kRr7TU0ohjsrtBt_ZpoNimHunZZ3B3F-f0Zgdx_v2OAv2CO1qnfvZbiHTn5zW9DLPfxLH3HUbIOtJv44xZhJ76kJ8s0wCB1hi33mWthuAw0iWuIIt9T1c-4CvyooN-wtPH_YT8-Hj1vV4uVl-vP9WXq4UrhZoXLXdMiAKMAtNp2bWScWWUKaEBVzWidLztwDiHTVMWsgIsdSNly7h2BpUUJ-TDg-8mNQO2LueM0NtN9APEX3YEb_--CX5tf45bK6U20vBscPZoEMe7hNNsBz-53AYEHNNkOa9yHJEL_hctDC-rSgkuMvr2H_R2TDHkn8hUmc24UXvq_IFycZymiN0hd8Hsfvj2MPzMvnna6IH8M2pxDzqVqWM</recordid><startdate>20170725</startdate><enddate>20170725</enddate><creator>Salazar-Aguilar, Sandra</creator><creator>Ruiz-Posadas, Lucero Del Mar</creator><creator>Cadena-Iñiguez, Jorge</creator><creator>Soto-Hernández, Marcos</creator><creator>Santiago-Osorio, Edelmiro</creator><creator>Aguiñiga-Sánchez, Itzen</creator><creator>Rivera-Martínez, Ana Rocío</creator><creator>Aguirre-Medina, Juan Francisco</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8269-7854</orcidid><orcidid>https://orcid.org/0000-0001-8577-7991</orcidid></search><sort><creationdate>20170725</creationdate><title>Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line</title><author>Salazar-Aguilar, Sandra ; Ruiz-Posadas, Lucero Del Mar ; Cadena-Iñiguez, Jorge ; Soto-Hernández, Marcos ; Santiago-Osorio, Edelmiro ; Aguiñiga-Sánchez, Itzen ; Rivera-Martínez, Ana Rocío ; Aguirre-Medina, Juan Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-d2c0331a96a9f75fd50269694abac8b34c2dfa9ccebb4158ae47b55d027c9e653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>apigenin</topic><topic>Apigenin - pharmacology</topic><topic>bioactive properties</topic><topic>Biological activity</topic><topic>Biological effects</topic><topic>Biological materials</topic><topic>Biomedical materials</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Chromatography</topic><topic>Column chromatography</topic><topic>Cucurbitaceae - chemistry</topic><topic>cucurbitacins</topic><topic>Cucurbitacins - pharmacology</topic><topic>cultivars</topic><topic>Female</topic><topic>Flavanones - pharmacology</topic><topic>Flavonoids</topic><topic>Flavonoids - pharmacology</topic><topic>Fruit - chemistry</topic><topic>fruits</topic><topic>HeLa Cells</topic><topic>High performance liquid chromatography</topic><topic>human cell lines</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Liquid chromatography</topic><topic>Lymphocytes</topic><topic>myricetin</topic><topic>Naringenin</topic><topic>neoplasm cells</topic><topic>new variety</topic><topic>Perla</topic><topic>Phloretin - pharmacology</topic><topic>Phytochemicals - pharmacology</topic><topic>Plant Extracts - pharmacology</topic><topic>Quercetin</topic><topic>Quercetin - pharmacology</topic><topic>Rutin</topic><topic>Rutin - pharmacology</topic><topic>Sechium edule</topic><topic>Thin layer chromatography</topic><topic>Tumor cell lines</topic><topic>Tumor cells</topic><topic>uterine cervical neoplasms</topic><topic>Uterine Cervical Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salazar-Aguilar, Sandra</creatorcontrib><creatorcontrib>Ruiz-Posadas, Lucero Del Mar</creatorcontrib><creatorcontrib>Cadena-Iñiguez, Jorge</creatorcontrib><creatorcontrib>Soto-Hernández, Marcos</creatorcontrib><creatorcontrib>Santiago-Osorio, Edelmiro</creatorcontrib><creatorcontrib>Aguiñiga-Sánchez, Itzen</creatorcontrib><creatorcontrib>Rivera-Martínez, Ana Rocío</creatorcontrib><creatorcontrib>Aguirre-Medina, Juan Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salazar-Aguilar, Sandra</au><au>Ruiz-Posadas, Lucero Del Mar</au><au>Cadena-Iñiguez, Jorge</au><au>Soto-Hernández, Marcos</au><au>Santiago-Osorio, Edelmiro</au><au>Aguiñiga-Sánchez, Itzen</au><au>Rivera-Martínez, Ana Rocío</au><au>Aguirre-Medina, Juan Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-07-25</date><risdate>2017</risdate><volume>9</volume><issue>8</issue><spage>798</spage><pages>798-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>The
Perla Negra cultivar is a recently-obtained biological material whose progenitors are
var.
and
var.
the latter of which has been reported to have antiproliferative activity against the HeLa P-388 and L-929 cancer cell lines. The present study aimed to determine if the methanolic extract of the fruit of the Perla Negra cultivar had the same biological activity. The methanolic extract was phytochemically characterized by thin layer chromatography (TLC) and column chromatography (CC), identifying the terpenes and flavonoids. The compounds identified via high performance liquid chromatography (HPLC) were Cucurbitacins B, D, E, and I for the terpene fractions, and Rutin, Phlorizidin, Myricetin, Quercetin, Naringenin, Phloretin, Apigenin, and Galangin for the flavonoid fractions). Biological activity was evaluated with different concentrations of the methanolic extract in the HeLa cell line and normal lymphocytes. The methanolic extract inhibited the proliferation of HeLa cells (IC
1.85 µg·mL
), but the lymphocytes were affected by the extract (IC
30.04 µg·mL
). Some fractions, and the pool of all of them, showed inhibition higher than 80% at a concentration of 2.11 µg·mL
. Therefore, the biological effect shown by the methanolic extract of the Perla Negra has some specificity in inhibiting tumor cells and not normal cells; an unusual feature among molecules investigated as potential biomedical agents.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28757593</pmid><doi>10.3390/nu9080798</doi><orcidid>https://orcid.org/0000-0002-8269-7854</orcidid><orcidid>https://orcid.org/0000-0001-8577-7991</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2017-07, Vol.9 (8), p.798 |
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| language | eng |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Antineoplastic Agents, Phytogenic - pharmacology apigenin Apigenin - pharmacology bioactive properties Biological activity Biological effects Biological materials Biomedical materials Cell proliferation Cell Proliferation - drug effects Cervical cancer Cervix Chromatography Column chromatography Cucurbitaceae - chemistry cucurbitacins Cucurbitacins - pharmacology cultivars Female Flavanones - pharmacology Flavonoids Flavonoids - pharmacology Fruit - chemistry fruits HeLa Cells High performance liquid chromatography human cell lines Humans Inhibitory Concentration 50 Liquid chromatography Lymphocytes myricetin Naringenin neoplasm cells new variety Perla Phloretin - pharmacology Phytochemicals - pharmacology Plant Extracts - pharmacology Quercetin Quercetin - pharmacology Rutin Rutin - pharmacology Sechium edule Thin layer chromatography Tumor cell lines Tumor cells uterine cervical neoplasms Uterine Cervical Neoplasms - drug therapy |
| title | Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line |
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