Efavirenz decreases etonogestrel exposure: a pharmacokinetic evaluation of implantable contraception with antiretroviral therapy

OBJECTIVES:The primary objective of this study was to characterize the pharmacokinetics of etonogestrel (ENG) released from a contraceptive implant in Ugandan women living with HIV who were receiving efavirenz (EFV) or nevirapine (NVP)-based antiretroviral therapy (ART), compared with ART-naive wome...

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Veröffentlicht in:	AIDS (London) 2017-09, Vol.31 (14), p.1965-1972
Hauptverfasser:	Chappell, Catherine A, Lamorde, Mohammed, Nakalema, Shadia, Chen, Beatrice A, Mackline, Hope, Riddler, Sharon A, Cohn, Susan E, Darin, Kristin M, Achilles, Sharon L, Scarsi, Kimberly K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS/HIV Anti-Retroviral Agents - administration & dosage Benzoxazines - administration & dosage Contraception - methods Contraceptive Agents, Female - administration & dosage Contraceptive Agents, Female - pharmacokinetics Desogestrel - administration & dosage Desogestrel - pharmacokinetics Drug Antagonism Female HIV Infections - drug therapy Humans Middle Aged Nevirapine - administration & dosage Uganda Young Adult
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