Biofilms in Endodontics-Current Status and Future Directions
Microbiota are found in highly organized and complex entities, known as biofilms, the characteristics of which are fundamentally different from microbes in planktonic suspensions. Root canal infections are biofilm mediated. The complexity and variability of the root canal system, together with the m...
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Veröffentlicht in: | International journal of molecular sciences 2017-08, Vol.18 (8), p.1748 |
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creator | Neelakantan, Prasanna Romero, Monica Vera, Jorge Daood, Umer Khan, Asad U Yan, Aixin Cheung, Gary Shun Pan |
description | Microbiota are found in highly organized and complex entities, known as biofilms, the characteristics of which are fundamentally different from microbes in planktonic suspensions. Root canal infections are biofilm mediated. The complexity and variability of the root canal system, together with the multi-species nature of biofilms, make disinfection of this system extremely challenging. Microbial persistence appears to be the most important factor for failure of root canal treatment and this could further have an impact on pain and quality of life. Biofilm removal is accomplished by a chemo-mechanical process, using specific instruments and disinfecting chemicals in the form of irrigants and/or intracanal medicaments. Endodontic research has focused on the characterization of root canal biofilms and the clinical methods to disrupt the biofilms in addition to achieving microbial killing. In this narrative review, we discuss the role of microbial biofilms in endodontics and review the literature on the role of root canal disinfectants and disinfectant-activating methods on biofilm removal. |
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Root canal infections are biofilm mediated. The complexity and variability of the root canal system, together with the multi-species nature of biofilms, make disinfection of this system extremely challenging. Microbial persistence appears to be the most important factor for failure of root canal treatment and this could further have an impact on pain and quality of life. Biofilm removal is accomplished by a chemo-mechanical process, using specific instruments and disinfecting chemicals in the form of irrigants and/or intracanal medicaments. Endodontic research has focused on the characterization of root canal biofilms and the clinical methods to disrupt the biofilms in addition to achieving microbial killing. 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In this narrative review, we discuss the role of microbial biofilms in endodontics and review the literature on the role of root canal disinfectants and disinfectant-activating methods on biofilm removal.</description><subject>Animals</subject><subject>Biofilms</subject><subject>Dental Pulp Cavity - microbiology</subject><subject>Disinfectants</subject><subject>Disinfection</subject><subject>Disinfection & disinfectants</subject><subject>Endodontics</subject><subject>Endodontics - methods</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Pain</subject><subject>Quality of life</subject><subject>Review</subject><subject>Root Canal Therapy - methods</subject><subject>Root canals</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1LxDAUxIMoft88S8GLB6svSbNJQARdP2HBg3oOaZJqljbRpBX8762syurpDbwfwwyD0B6GY0olnPh5l7EAgXklVtAmrggpASZ8dUlvoK2c5wCEEibX0QYRAgA420SnFz42vu1y4UNxFWy0MfTe5HI6pORCXzz0uh9yoYMtrod-SK649MmZ3seQd9Bao9vsdr_vNnq6vnqc3paz-5u76fmsNJRwUVLDcW2pJabSjjM8mWggFWeU87q2FdVAAVstpeXQ1BWjshZcgnSN0cJwQ7fR2cL3dag7Z82YK-lWvSbf6fShovbq7yf4F_Uc3xVjXGAqRoPDb4MU3waXe9X5bFzb6uDikBWWRDDgEwkjevAPncchhbHeSFEpGMGUjdTRgjIp5pxc8xsGg_qaRS3PMuL7ywV-4Z8d6Cd6Vohp</recordid><startdate>20170811</startdate><enddate>20170811</enddate><creator>Neelakantan, Prasanna</creator><creator>Romero, Monica</creator><creator>Vera, Jorge</creator><creator>Daood, Umer</creator><creator>Khan, Asad U</creator><creator>Yan, Aixin</creator><creator>Cheung, Gary Shun Pan</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170811</creationdate><title>Biofilms in Endodontics-Current Status and Future Directions</title><author>Neelakantan, Prasanna ; 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subjects | Animals Biofilms Dental Pulp Cavity - microbiology Disinfectants Disinfection Disinfection & disinfectants Endodontics Endodontics - methods Humans Literature reviews Microbiology Microorganisms Pain Quality of life Review Root Canal Therapy - methods Root canals |
title | Biofilms in Endodontics-Current Status and Future Directions |
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