Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women
ABSTRACT Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the...
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| Veröffentlicht in: | Journal of bone and mineral research 2017-02, Vol.32 (2), p.237-242 |
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| creator | Carrelli, Angela Bucovsky, Mariana Horst, Ronald Cremers, Serge Zhang, Chengchen Bessler, Marc Schrope, Beth Evanko, John Blanco, Jody Silverberg, Shonni J Stein, Emily M |
| description | ABSTRACT
Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the relationship between body composition, serum 25‐hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. Obese women undergoing bariatric surgery and normal‐weight women undergoing abdominal surgery for benign gynecologic conditions were enrolled. Subjects had measurements of serum 25OHD by high‐performance liquid chromatography (HPLC) and body composition by dual‐energy X‐ray absorptiometry (DXA). Vitamin D concentrations in SQ and OM adipose were measured by mass spectroscopy. Thirty‐six women were enrolled. Serum 25OHD was similar between groups (OB 27 ± 2 versus C 26 ± 2 ng/mL; p = 0.71). Adipose vitamin D concentrations were not significantly different in either SQ (OB 34 ± 9 versus C 26 ± 12 ng/g; p = 0.63) or OM compartments (OB 51 ± 13 versus C 30 ± 18 ng/g; p = 0.37). The distribution of vitamin D between SQ and OM compartments was similar between groups. Serum 25OHD was directly related to adipose vitamin D in both groups. Total body vitamin D stores were significantly greater in OB than in C (2.3 ± 0.6 versus 0.4 ± 0.8 mg, respectively; p |
| doi_str_mv | 10.1002/jbmr.2979 |
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Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the relationship between body composition, serum 25‐hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. Obese women undergoing bariatric surgery and normal‐weight women undergoing abdominal surgery for benign gynecologic conditions were enrolled. Subjects had measurements of serum 25OHD by high‐performance liquid chromatography (HPLC) and body composition by dual‐energy X‐ray absorptiometry (DXA). Vitamin D concentrations in SQ and OM adipose were measured by mass spectroscopy. Thirty‐six women were enrolled. Serum 25OHD was similar between groups (OB 27 ± 2 versus C 26 ± 2 ng/mL; p = 0.71). Adipose vitamin D concentrations were not significantly different in either SQ (OB 34 ± 9 versus C 26 ± 12 ng/g; p = 0.63) or OM compartments (OB 51 ± 13 versus C 30 ± 18 ng/g; p = 0.37). The distribution of vitamin D between SQ and OM compartments was similar between groups. Serum 25OHD was directly related to adipose vitamin D in both groups. Total body vitamin D stores were significantly greater in OB than in C (2.3 ± 0.6 versus 0.4 ± 0.8 mg, respectively; p < 0.01). In summary, although OB had significantly greater total vitamin D stores than C, the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the OM and SQ fat compartments was similar. Our data demonstrate that obese subjects have greater adipose stores of vitamin D. They support the hypotheses that the enlarged adipose mass in obese individuals serves as a reservoir for vitamin D and that the increased amount of vitamin D required to saturate this depot may predispose obese individuals to inadequate serum 25OHD. © 2016 American Society for Bone and Mineral Research.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1002/jbmr.2979</identifier><identifier>PMID: 27542960</identifier><identifier>CODEN: JBMREJ</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adipose Tissue - metabolism ; Adiposity ; Adult ; Body Weight ; BONE‐FAT INTERACTIONS ; DISORDERS OF CALCIUM/PHOSPHATE METABOLISM ; Female ; Humans ; NUTRITION ; Obesity - metabolism ; Omentum - metabolism ; Subcutaneous Fat - metabolism ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - metabolism</subject><ispartof>Journal of bone and mineral research, 2017-02, Vol.32 (2), p.237-242</ispartof><rights>2016 American Society for Bone and Mineral Research</rights><rights>2016 American Society for Bone and Mineral Research.</rights><rights>2017 American Society for Bone and Mineral Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5429-4b4acc36ecbb936383ba1b11d0bbfe7ff531891a6c7d9cae2661c10370333b183</citedby><cites>FETCH-LOGICAL-c5429-4b4acc36ecbb936383ba1b11d0bbfe7ff531891a6c7d9cae2661c10370333b183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbmr.2979$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbmr.2979$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27542960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrelli, Angela</creatorcontrib><creatorcontrib>Bucovsky, Mariana</creatorcontrib><creatorcontrib>Horst, Ronald</creatorcontrib><creatorcontrib>Cremers, Serge</creatorcontrib><creatorcontrib>Zhang, Chengchen</creatorcontrib><creatorcontrib>Bessler, Marc</creatorcontrib><creatorcontrib>Schrope, Beth</creatorcontrib><creatorcontrib>Evanko, John</creatorcontrib><creatorcontrib>Blanco, Jody</creatorcontrib><creatorcontrib>Silverberg, Shonni J</creatorcontrib><creatorcontrib>Stein, Emily M</creatorcontrib><title>Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>ABSTRACT
Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the relationship between body composition, serum 25‐hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. Obese women undergoing bariatric surgery and normal‐weight women undergoing abdominal surgery for benign gynecologic conditions were enrolled. Subjects had measurements of serum 25OHD by high‐performance liquid chromatography (HPLC) and body composition by dual‐energy X‐ray absorptiometry (DXA). Vitamin D concentrations in SQ and OM adipose were measured by mass spectroscopy. Thirty‐six women were enrolled. Serum 25OHD was similar between groups (OB 27 ± 2 versus C 26 ± 2 ng/mL; p = 0.71). Adipose vitamin D concentrations were not significantly different in either SQ (OB 34 ± 9 versus C 26 ± 12 ng/g; p = 0.63) or OM compartments (OB 51 ± 13 versus C 30 ± 18 ng/g; p = 0.37). The distribution of vitamin D between SQ and OM compartments was similar between groups. Serum 25OHD was directly related to adipose vitamin D in both groups. Total body vitamin D stores were significantly greater in OB than in C (2.3 ± 0.6 versus 0.4 ± 0.8 mg, respectively; p < 0.01). In summary, although OB had significantly greater total vitamin D stores than C, the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the OM and SQ fat compartments was similar. Our data demonstrate that obese subjects have greater adipose stores of vitamin D. They support the hypotheses that the enlarged adipose mass in obese individuals serves as a reservoir for vitamin D and that the increased amount of vitamin D required to saturate this depot may predispose obese individuals to inadequate serum 25OHD. © 2016 American Society for Bone and Mineral Research.</description><subject>Adipose Tissue - metabolism</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Body Weight</subject><subject>BONE‐FAT INTERACTIONS</subject><subject>DISORDERS OF CALCIUM/PHOSPHATE METABOLISM</subject><subject>Female</subject><subject>Humans</subject><subject>NUTRITION</subject><subject>Obesity - metabolism</subject><subject>Omentum - metabolism</subject><subject>Subcutaneous Fat - metabolism</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - metabolism</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAURi0EokNhwR9AltjAIq1vHD-yQeqDpwqVoNClZTs3U4-SeLATUP89CVMqQEJiZV356NzHR8hjYAfAWHm4cX06KGtV3yErECUvKqnhLlkxrauCVRz2yIOcN4wxKaS8T_ZKJaqylmxFTr-E0fZhoKf00xiTXSOdi6MmbGNGehFynpDGlp47nGs7NPRDTL3t6CWG9dVIL2OPw0Nyr7Vdxkc37z75_Orlxcmb4uz89duTo7PCL-2KylXWey7RO1dzyTV3FhxAw5xrUbWt4KBrsNKrpvYWSynBA-OKcc4daL5PXuy828n12HgcxmQ7s02ht-naRBvMnz9DuDLr-M0IoZTQ9Sx4diNI8euEeTR9yB67zg4Yp2xAS82ZlCX8B8qFKJWqqxl9-he6iVMa5ksswkoqBbD0fr6jfIo5J2xv5wZmlhjNEqNZYpzZJ78vekv-ym0GDnfA99Dh9b9N5t3x-48_lT8A0PKmHw</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Carrelli, Angela</creator><creator>Bucovsky, Mariana</creator><creator>Horst, Ronald</creator><creator>Cremers, Serge</creator><creator>Zhang, Chengchen</creator><creator>Bessler, Marc</creator><creator>Schrope, Beth</creator><creator>Evanko, John</creator><creator>Blanco, Jody</creator><creator>Silverberg, Shonni J</creator><creator>Stein, Emily M</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201702</creationdate><title>Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women</title><author>Carrelli, Angela ; Bucovsky, Mariana ; Horst, Ronald ; Cremers, Serge ; Zhang, Chengchen ; Bessler, Marc ; Schrope, Beth ; Evanko, John ; Blanco, Jody ; Silverberg, Shonni J ; Stein, Emily M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5429-4b4acc36ecbb936383ba1b11d0bbfe7ff531891a6c7d9cae2661c10370333b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Body Weight</topic><topic>BONE‐FAT INTERACTIONS</topic><topic>DISORDERS OF CALCIUM/PHOSPHATE METABOLISM</topic><topic>Female</topic><topic>Humans</topic><topic>NUTRITION</topic><topic>Obesity - metabolism</topic><topic>Omentum - metabolism</topic><topic>Subcutaneous Fat - metabolism</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrelli, Angela</creatorcontrib><creatorcontrib>Bucovsky, Mariana</creatorcontrib><creatorcontrib>Horst, Ronald</creatorcontrib><creatorcontrib>Cremers, Serge</creatorcontrib><creatorcontrib>Zhang, Chengchen</creatorcontrib><creatorcontrib>Bessler, Marc</creatorcontrib><creatorcontrib>Schrope, Beth</creatorcontrib><creatorcontrib>Evanko, John</creatorcontrib><creatorcontrib>Blanco, Jody</creatorcontrib><creatorcontrib>Silverberg, Shonni J</creatorcontrib><creatorcontrib>Stein, Emily M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrelli, Angela</au><au>Bucovsky, Mariana</au><au>Horst, Ronald</au><au>Cremers, Serge</au><au>Zhang, Chengchen</au><au>Bessler, Marc</au><au>Schrope, Beth</au><au>Evanko, John</au><au>Blanco, Jody</au><au>Silverberg, Shonni J</au><au>Stein, Emily M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2017-02</date><risdate>2017</risdate><volume>32</volume><issue>2</issue><spage>237</spage><epage>242</epage><pages>237-242</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><coden>JBMREJ</coden><abstract>ABSTRACT
Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the relationship between body composition, serum 25‐hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. Obese women undergoing bariatric surgery and normal‐weight women undergoing abdominal surgery for benign gynecologic conditions were enrolled. Subjects had measurements of serum 25OHD by high‐performance liquid chromatography (HPLC) and body composition by dual‐energy X‐ray absorptiometry (DXA). Vitamin D concentrations in SQ and OM adipose were measured by mass spectroscopy. Thirty‐six women were enrolled. Serum 25OHD was similar between groups (OB 27 ± 2 versus C 26 ± 2 ng/mL; p = 0.71). Adipose vitamin D concentrations were not significantly different in either SQ (OB 34 ± 9 versus C 26 ± 12 ng/g; p = 0.63) or OM compartments (OB 51 ± 13 versus C 30 ± 18 ng/g; p = 0.37). The distribution of vitamin D between SQ and OM compartments was similar between groups. Serum 25OHD was directly related to adipose vitamin D in both groups. Total body vitamin D stores were significantly greater in OB than in C (2.3 ± 0.6 versus 0.4 ± 0.8 mg, respectively; p < 0.01). In summary, although OB had significantly greater total vitamin D stores than C, the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the OM and SQ fat compartments was similar. Our data demonstrate that obese subjects have greater adipose stores of vitamin D. They support the hypotheses that the enlarged adipose mass in obese individuals serves as a reservoir for vitamin D and that the increased amount of vitamin D required to saturate this depot may predispose obese individuals to inadequate serum 25OHD. © 2016 American Society for Bone and Mineral Research.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27542960</pmid><doi>10.1002/jbmr.2979</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue - metabolism Adiposity Adult Body Weight BONE‐FAT INTERACTIONS DISORDERS OF CALCIUM/PHOSPHATE METABOLISM Female Humans NUTRITION Obesity - metabolism Omentum - metabolism Subcutaneous Fat - metabolism Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - metabolism |
| title | Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women |
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