Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is markedly overexpressed by cyst epithelial cells. Periost...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2017-09, Vol.28 (9), p.2708-2719
Hauptverfasser:	Raman, Archana, Reif, Gail A, Dai, Yuqiao, Khanna, Aditi, Li, Xiaogang, Astleford, Lindsay, Parnell, Stephen C, Calvet, James P, Wallace, Darren P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Basic Research Cell Adhesion Molecules - metabolism Cell Proliferation - genetics Dilatation, Pathologic - genetics Disease Progression Fibrosis Gene Silencing Heterozygote Homozygote Humans Kidney Tubules, Collecting - pathology Male Mice Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - pathology Polycystic Kidney, Autosomal Dominant - physiopathology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Renal Insufficiency - genetics Signal Transduction TOR Serine-Threonine Kinases - metabolism
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