MicroRNA-23a and MicroRNA-27a Mimic Exercise by Ameliorating CKD-Induced Muscle Atrophy

Muscle atrophy is a frequent complication of CKD, and exercise can attenuate the process. This study investigated the role of microRNA-23a (miR-23a) and miR-27a in the regulation of muscle mass in mice with CKD. These miRs are located in a gene cluster that is regulated by the transcription factor N...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2017-09, Vol.28 (9), p.2631-2640
Hauptverfasser:	Wang, Bin, Zhang, Cong, Zhang, Aiqing, Cai, Hui, Price, S Russ, Wang, Xiaonan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy - etiology Atrophy - genetics Atrophy - metabolism Atrophy - prevention & control Basic Research Caspase 3 - metabolism Caspase 7 - metabolism Cytokines - genetics Forkhead Box Protein O1 - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism Muscle Proteins - metabolism Muscle Strength Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Myostatin - metabolism Phosphorylation Physical Conditioning, Animal - physiology Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Renal Insufficiency, Chronic - complications RNA, Messenger - metabolism Signal Transduction SKP Cullin F-Box Protein Ligases - metabolism Smad2 Protein - metabolism Smad3 Protein - metabolism Transduction, Genetic Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - metabolism
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