Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation

Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategi...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2017-08, Vol.57 (2), p.193-203
Hauptverfasser:	Dolinay, Tamas, Himes, Blanca E, Shumyatcher, Maya, Lawrence, Gladys Gray, Margulies, Susan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - antagonists & inhibitors Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - physiology Adenine - analogs & derivatives Adenine - pharmacology Adenine - therapeutic use Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Alveoli Animals Apoptosis Cell Death Cell Membrane Permeability Cells, Cultured Cytokines Cytokines - secretion Drug Evaluation, Preclinical Edema eIF-2 Kinase - antagonists & inhibitors eIF-2 Kinase - genetics eIF-2 Kinase - physiology Endoplasmic reticulum Enzyme Activation Epithelium Gene Expression Regulation Hypoxia Indoles - pharmacology Indoles - therapeutic use Infections Inflammation Kinases Lungs Mechanical ventilation Original Research Ostomy Pathology Permeability Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Protein kinase Proteins Pulmonary Edema - drug therapy Pulmonary Edema - etiology Rats Rats, Sprague-Dawley Respiratory distress syndrome Ribonucleic acid RNA RNA Interference Rodents Signal Transduction Stress response Stress, Mechanical Stress, Physiological - physiology Studies Therapeutic targets Transcription Factor CHOP - antagonists & inhibitors Transcription Factor CHOP - genetics Transcription Factor CHOP - physiology Transcription factors Unfolded Protein Response Ventilator-Induced Lung Injury - physiopathology Ventilators
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