Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury

BACKGROUND:Adult mammalian hearts have a limited ability to generate new cardiomyocytes. Proliferation of existing adult cardiomyocytes (ACMs) is a potential source of new cardiomyocytes. Understanding the fundamental biology of ACM proliferation could be of great clinical significance for treating...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2017-08, Vol.136 (9), p.834-848
Hauptverfasser:	Wang, Wei Eric, Li, Liangpeng, Xia, Xuewei, Fu, Wenbin, Liao, Qiao, Lan, Cong, Yang, Dezhong, Chen, Hongmei, Yue, Rongchuan, Zeng, Cindy, Zhou, Lin, Zhou, Bin, Duan, Dayue Darrel, Chen, Xiongwen, Houser, Steven R, Zeng, Chunyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Proliferation Cell Survival Cells, Cultured Connexin 43 - antagonists & inhibitors Connexin 43 - genetics Connexin 43 - metabolism Cytokinesis Echocardiography Gap Junctions - metabolism Heart - diagnostic imaging Humans Mice Mice, Transgenic Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Rats RNA Interference Signal Transduction Troponin I - metabolism
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