Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult‐onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany

Aim To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population. Methods For this cross‐sectional study we recruited people with adult‐onset diabetes (age of diagnosis 20–60 years), at tertiary referral centres in Germany (n=1020) and Sin...

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Veröffentlicht in:	Diabetic medicine 2017-08, Vol.34 (8), p.1145-1153
Hauptverfasser:	Ong, Y. H., Koh, W. C. A., Ng, M. L., Tam, Z. Y., Lim, S. C., Boehm, B. O., Blagieva, R., Boehm, J., Brückel, J., Claudi‐Boehm, S., Haak, T., Haenle, M., Höpfer, S., Jütting, G., Kleger, A., Kratzer, W., Kurkhaus, A., Lippmann‐Grob, B., Manfras, B., Merger, S., Rosinger, S., Schilling, S., Seufferlein, T., Sing, R., Trischler, G., Ali, Y., Bee, Y. M., Chew, D. E. K., Chia, K. S., Dalan, R., Khoo, C.M., Lee, E. S., Leow, M. K., Lim, S.C., Ng, S. P., Sim, X., Srinivasan, D. K., Sum, C. F., Tai, E.S., Tan, W. E., Tavintharan, S., Toh, M. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Antibodies Antigens Asian People Autoantibodies - analysis Autoimmune diseases Autoimmune Diseases - blood Autoimmune Diseases - epidemiology Autoimmune Diseases - ethnology Autoimmune Diseases - immunology Autoimmunity Biomarkers - blood Cohort Studies Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - immunology Ethnicity Germany - epidemiology Glutamate decarboxylase Glutamate Decarboxylase - antagonists & inhibitors Glutamic acid Humans Immunoglobulins Male Middle Aged Minority & ethnic groups Population studies Prevalence Receptor-Like Protein Tyrosine Phosphatases, Class 8 - antagonists & inhibitors Referral and Consultation Research: Metabolism Singapore - epidemiology Standardization Tertiary Care Centers White People Young Adult
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Zusammenfassung:	Aim To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population. Methods For this cross‐sectional study we recruited people with adult‐onset diabetes (age of diagnosis 20–60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols. Results The prevalence of glutamic acid decarboxylase antibody positivity was 13.9% (95% CI 12.1–16.0; P
ISSN:	0742-3071 1464-5491
DOI:	10.1111/dme.13358