Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis

Pachydermoperiostosis (PDP) is a rare inherited multisystem disease characterized with digital clubbing, pachydermia and periostosis. Variants in either HPGD or SLCO2A1 that interrupt the prostaglandin E2 (PGE 2 ) pathway have been shown to be involved in PDP. Here, in addition to six confirmed vari...

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Veröffentlicht in:	Scientific reports 2017-08, Vol.7 (1), p.9686-9, Article 9686
Hauptverfasser:	Huang, Hui, Wang, Yongjun, Cao, Yong, Wu, Boda, Li, Yonggui, Fan, Liangliang, Tan, Zhiping, Jiang, Yi, Tang, Jianguang, Hu, Jianzhong, Shi, Xiaoliu
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxyprostaglandin dehydrogenase (NAD+) 45/23 631/208/2489/1512 692/4020/2741/533 Arthralgia Biomarkers Biopsy Celecoxib Celecoxib - therapeutic use Cytokines DNA Mutational Analysis Gastric mucosa Gastric Mucosa - metabolism Gastric Mucosa - pathology Humanities and Social Sciences Humans Hyperplasia Hypertrophy Immunohistochemistry Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Ligands Male Molecular modelling Mucous membrane multidisciplinary Mutation Necrosis Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Osteoarthropathy, Primary Hypertrophic - drug therapy Osteoarthropathy, Primary Hypertrophic - genetics Osteoarthropathy, Primary Hypertrophic - metabolism Osteoarthropathy, Primary Hypertrophic - pathology Pedigree Phenotype Prostaglandin E2 RANK Ligand - genetics RANK Ligand - metabolism Science Science (multidisciplinary) TRANCE protein Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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