Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters
Purpose. To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods. Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coher...
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| description | Purpose. To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods. Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results. The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion. CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age. |
| doi_str_mv | 10.1155/2017/3684971 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5574220</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A557301817</galeid><sourcerecordid>A557301817</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-a54160495e00ac19f7f6ac9dc8d32213f9b2c49e97104804b53bbde1b40428983</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhiMEolXbG2cUiQsSpPXYjhNfkJZVKUiVQBVw4GJNnMmuq6zd2tlW_fd42WULnPDFM5pH73y8RfEC2ClAXZ9xBs2ZUK3UDTwpDrkAWSmQ8HQfC3FQnKR0zfJrQTGtnhcHXAOTbcMOix-zBVVXNOJEffkdo8PJBZ_KMJRX2HVuKuchesKxvKCwoik6m2P0fTkfnf-VvHe5YJe4zb5gxMxRTMfFswHHRCe7_6j49uH86_xjdfn54tN8dllZqfVUYS3zWFLXxBha0EMzKLS6t20vOAcx6I5nkvKGeWYmu1p0XU_QSSZ5q1txVLzb6t6suxX1lvwUcTQ30a0wPpiAzvxd8W5pFuHO1HUjOWdZ4PVOIIbbNaXJrFyyNI7oKayTAa2ACclrldFX_6DXYR19Xi9TgjeCMyUeqQWOZJwfQu5rN6JmlpsKBi00mXq7pWwMKUUa9iMDMxt3zcZds3M34y__XHMP__YyA2-2wNL5Hu_df8pRZmjARxqE2lzlJ4WutAw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932732063</pqid></control><display><type>article</type><title>Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhang, Di ; Cao, Xiaomeng ; Qin, Xiao ; Zhang, Haixia ; Li, Lin</creator><contributor>Georgalas, Ilias</contributor><creatorcontrib>Zhang, Di ; Cao, Xiaomeng ; Qin, Xiao ; Zhang, Haixia ; Li, Lin ; Georgalas, Ilias</creatorcontrib><description>Purpose. To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods. Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results. The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion. CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/3684971</identifier><identifier>PMID: 29104870</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Aging ; Aging - pathology ; Aging - physiology ; Animals ; Biomechanical Phenomena ; Biomechanics ; Contact lenses ; Cornea ; Cornea - diagnostic imaging ; Cornea - physiopathology ; Cornea - ultrastructure ; Correlation ; Curvature ; Eye ; Humans ; Intraocular pressure ; Intraocular Pressure - physiology ; Mathematical analysis ; Optical Coherence Tomography ; Physiological aspects ; Pressure ; Rabbits ; Resistance factors ; Skin & tissue grafts ; Structure ; Tomography, Optical Coherence ; Tonometry, Ocular ; Viscoelasticity</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-11</ispartof><rights>Copyright © 2017 Haixia Zhang et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Haixia Zhang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Haixia Zhang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-a54160495e00ac19f7f6ac9dc8d32213f9b2c49e97104804b53bbde1b40428983</citedby><cites>FETCH-LOGICAL-c499t-a54160495e00ac19f7f6ac9dc8d32213f9b2c49e97104804b53bbde1b40428983</cites><orcidid>0000-0002-9190-5475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574220/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574220/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29104870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Georgalas, Ilias</contributor><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Cao, Xiaomeng</creatorcontrib><creatorcontrib>Qin, Xiao</creatorcontrib><creatorcontrib>Zhang, Haixia</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><title>Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Purpose. To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods. Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results. The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion. CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.</description><subject>Age</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Contact lenses</subject><subject>Cornea</subject><subject>Cornea - diagnostic imaging</subject><subject>Cornea - physiopathology</subject><subject>Cornea - ultrastructure</subject><subject>Correlation</subject><subject>Curvature</subject><subject>Eye</subject><subject>Humans</subject><subject>Intraocular pressure</subject><subject>Intraocular Pressure - physiology</subject><subject>Mathematical analysis</subject><subject>Optical Coherence Tomography</subject><subject>Physiological aspects</subject><subject>Pressure</subject><subject>Rabbits</subject><subject>Resistance factors</subject><subject>Skin & tissue grafts</subject><subject>Structure</subject><subject>Tomography, Optical Coherence</subject><subject>Tonometry, Ocular</subject><subject>Viscoelasticity</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1v1DAQhiMEolXbG2cUiQsSpPXYjhNfkJZVKUiVQBVw4GJNnMmuq6zd2tlW_fd42WULnPDFM5pH73y8RfEC2ClAXZ9xBs2ZUK3UDTwpDrkAWSmQ8HQfC3FQnKR0zfJrQTGtnhcHXAOTbcMOix-zBVVXNOJEffkdo8PJBZ_KMJRX2HVuKuchesKxvKCwoik6m2P0fTkfnf-VvHe5YJe4zb5gxMxRTMfFswHHRCe7_6j49uH86_xjdfn54tN8dllZqfVUYS3zWFLXxBha0EMzKLS6t20vOAcx6I5nkvKGeWYmu1p0XU_QSSZ5q1txVLzb6t6suxX1lvwUcTQ30a0wPpiAzvxd8W5pFuHO1HUjOWdZ4PVOIIbbNaXJrFyyNI7oKayTAa2ACclrldFX_6DXYR19Xi9TgjeCMyUeqQWOZJwfQu5rN6JmlpsKBi00mXq7pWwMKUUa9iMDMxt3zcZds3M34y__XHMP__YyA2-2wNL5Hu_df8pRZmjARxqE2lzlJ4WutAw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Zhang, Di</creator><creator>Cao, Xiaomeng</creator><creator>Qin, Xiao</creator><creator>Zhang, Haixia</creator><creator>Li, Lin</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9190-5475</orcidid></search><sort><creationdate>20170101</creationdate><title>Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters</title><author>Zhang, Di ; Cao, Xiaomeng ; Qin, Xiao ; Zhang, Haixia ; Li, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-a54160495e00ac19f7f6ac9dc8d32213f9b2c49e97104804b53bbde1b40428983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Contact lenses</topic><topic>Cornea</topic><topic>Cornea - diagnostic imaging</topic><topic>Cornea - physiopathology</topic><topic>Cornea - ultrastructure</topic><topic>Correlation</topic><topic>Curvature</topic><topic>Eye</topic><topic>Humans</topic><topic>Intraocular pressure</topic><topic>Intraocular Pressure - physiology</topic><topic>Mathematical analysis</topic><topic>Optical Coherence Tomography</topic><topic>Physiological aspects</topic><topic>Pressure</topic><topic>Rabbits</topic><topic>Resistance factors</topic><topic>Skin & tissue grafts</topic><topic>Structure</topic><topic>Tomography, Optical Coherence</topic><topic>Tonometry, Ocular</topic><topic>Viscoelasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Cao, Xiaomeng</creatorcontrib><creatorcontrib>Qin, Xiao</creatorcontrib><creatorcontrib>Zhang, Haixia</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Di</au><au>Cao, Xiaomeng</au><au>Qin, Xiao</au><au>Zhang, Haixia</au><au>Li, Lin</au><au>Georgalas, Ilias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Purpose. To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods. Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results. The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion. CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29104870</pmid><doi>10.1155/2017/3684971</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9190-5475</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aging Aging - pathology Aging - physiology Animals Biomechanical Phenomena Biomechanics Contact lenses Cornea Cornea - diagnostic imaging Cornea - physiopathology Cornea - ultrastructure Correlation Curvature Eye Humans Intraocular pressure Intraocular Pressure - physiology Mathematical analysis Optical Coherence Tomography Physiological aspects Pressure Rabbits Resistance factors Skin & tissue grafts Structure Tomography, Optical Coherence Tonometry, Ocular Viscoelasticity |
| title | Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters |
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