Incidence of anaphylactic reactions after propofol administration in dogs
Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2017, Vol.79(8), pp.1446-1452 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | ONUMA, Mamoru TERADA, Misao ONO, Sadaharu MURAKAMI, Akiyoshi ISHIDA, Tomoko SANO, Tadashi |
| description | Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected. Following intravenous administration of propofol, the incidence of anaphylactic reactions and plasma histamine concentrations under general anesthesia maintained with isoflurane throughout surgery were compared between the two groups. The frequency of anaphylactic reactions and plasma histamine concentrations were compared by the chi-square test and Student t-test, respectively. The statistical significance for both tests was set at P |
| doi_str_mv | 10.1292/jvms.16-0550 |
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We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected. Following intravenous administration of propofol, the incidence of anaphylactic reactions and plasma histamine concentrations under general anesthesia maintained with isoflurane throughout surgery were compared between the two groups. The frequency of anaphylactic reactions and plasma histamine concentrations were compared by the chi-square test and Student t-test, respectively. The statistical significance for both tests was set at P<0.05. In the high- and normal-IgE groups, the average frequencies of anaphylactic reactions after propofol administration were 21.4 and 14.3%, and the mean plasma histamine concentrations were 167.9 ± 94.5 nM and 65.7 ± 40.3 nM, respectively. Animals of neither groups experienced shock-like symptoms. These results revealed that propofol might be relatively safe, although careful perioperative anesthesia monitoring and standby protocols are required when using propofol in dogs with a history of allergic diseases or high chicken- or soybean-specific IgE levels.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.16-0550</identifier><identifier>PMID: 28717055</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Anaphylaxis - chemically induced ; Anaphylaxis - veterinary ; anesthesia ; Anesthesia, General - adverse effects ; Anesthetics, Intravenous ; Animals ; dog ; Dog Diseases - chemically induced ; Dogs ; Egg Hypersensitivity ; Female ; histamine ; Hypnotics and Sedatives - adverse effects ; Immunoglobulin E - analysis ; immunoglobulin-E ; Incidence ; Lecithins - adverse effects ; Male ; Propofol - adverse effects ; propofol-induced anaphylaxis ; Retrospective Studies ; Soybean Oil - adverse effects ; Surgery</subject><ispartof>Journal of Veterinary Medical Science, 2017, Vol.79(8), pp.1446-1452</ispartof><rights>2017 by the Japanese Society of Veterinary Science</rights><rights>2017 The Japanese Society of Veterinary Science 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c678t-4790b719eea34054ba38190d3688b3fb7036bb8ae888c30c5fbbf72975c962dc3</citedby><cites>FETCH-LOGICAL-c678t-4790b719eea34054ba38190d3688b3fb7036bb8ae888c30c5fbbf72975c962dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573835/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573835/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28717055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ONUMA, Mamoru</creatorcontrib><creatorcontrib>TERADA, Misao</creatorcontrib><creatorcontrib>ONO, Sadaharu</creatorcontrib><creatorcontrib>MURAKAMI, Akiyoshi</creatorcontrib><creatorcontrib>ISHIDA, Tomoko</creatorcontrib><creatorcontrib>SANO, Tadashi</creatorcontrib><title>Incidence of anaphylactic reactions after propofol administration in dogs</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected. Following intravenous administration of propofol, the incidence of anaphylactic reactions and plasma histamine concentrations under general anesthesia maintained with isoflurane throughout surgery were compared between the two groups. The frequency of anaphylactic reactions and plasma histamine concentrations were compared by the chi-square test and Student t-test, respectively. The statistical significance for both tests was set at P<0.05. In the high- and normal-IgE groups, the average frequencies of anaphylactic reactions after propofol administration were 21.4 and 14.3%, and the mean plasma histamine concentrations were 167.9 ± 94.5 nM and 65.7 ± 40.3 nM, respectively. Animals of neither groups experienced shock-like symptoms. These results revealed that propofol might be relatively safe, although careful perioperative anesthesia monitoring and standby protocols are required when using propofol in dogs with a history of allergic diseases or high chicken- or soybean-specific IgE levels.</description><subject>Anaphylaxis - chemically induced</subject><subject>Anaphylaxis - veterinary</subject><subject>anesthesia</subject><subject>Anesthesia, General - adverse effects</subject><subject>Anesthetics, Intravenous</subject><subject>Animals</subject><subject>dog</subject><subject>Dog Diseases - chemically induced</subject><subject>Dogs</subject><subject>Egg Hypersensitivity</subject><subject>Female</subject><subject>histamine</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Immunoglobulin E - analysis</subject><subject>immunoglobulin-E</subject><subject>Incidence</subject><subject>Lecithins - adverse effects</subject><subject>Male</subject><subject>Propofol - adverse effects</subject><subject>propofol-induced anaphylaxis</subject><subject>Retrospective Studies</subject><subject>Soybean Oil - adverse effects</subject><subject>Surgery</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9r2zAYhsVYWdNut52HjzvUnX5YlnQZrKXdAoVe2rOQ5M-Jgi15khPIf18bp2G76AO9jx59vAh9JfiWUEV_7A59viV1iTnHH9CKsEqUomLqI1phNd0LyvElusp5hzElVa0-oUsqBRHTgxVar4PzDQQHRWwLE8ywPXbGjd4VCeYZQy5MO0IqhhSH2MauME3vg89jMnNc-FA0cZM_o4vWdBm-nOY1en18eLn_Uz49_17f_3oqXS3kWFZCYSuIAjCswryyhkmicMNqKS1rrcCstlYakFI6hh1vrW0FVYI7VdPGsWv0c_EOe9tD4yBMi3R6SL436aij8fr_JPit3sSD5lwwyfgk-H4SpPh3D3nUvc8Ous4EiPusiaKEMM6pnNCbBXUp5pygPX9DsJ7b13P7mtR6bn_Cv_272hl-r3sC7hZgl0ezgTNg0lR4B4tNKC3n42Q9h25rkobA3gD0IJqc</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>ONUMA, Mamoru</creator><creator>TERADA, Misao</creator><creator>ONO, Sadaharu</creator><creator>MURAKAMI, Akiyoshi</creator><creator>ISHIDA, Tomoko</creator><creator>SANO, Tadashi</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2017</creationdate><title>Incidence of anaphylactic reactions after propofol administration in dogs</title><author>ONUMA, Mamoru ; TERADA, Misao ; ONO, Sadaharu ; MURAKAMI, Akiyoshi ; ISHIDA, Tomoko ; SANO, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c678t-4790b719eea34054ba38190d3688b3fb7036bb8ae888c30c5fbbf72975c962dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anaphylaxis - chemically induced</topic><topic>Anaphylaxis - veterinary</topic><topic>anesthesia</topic><topic>Anesthesia, General - adverse effects</topic><topic>Anesthetics, Intravenous</topic><topic>Animals</topic><topic>dog</topic><topic>Dog Diseases - chemically induced</topic><topic>Dogs</topic><topic>Egg Hypersensitivity</topic><topic>Female</topic><topic>histamine</topic><topic>Hypnotics and Sedatives - adverse effects</topic><topic>Immunoglobulin E - analysis</topic><topic>immunoglobulin-E</topic><topic>Incidence</topic><topic>Lecithins - adverse effects</topic><topic>Male</topic><topic>Propofol - adverse effects</topic><topic>propofol-induced anaphylaxis</topic><topic>Retrospective Studies</topic><topic>Soybean Oil - adverse effects</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ONUMA, Mamoru</creatorcontrib><creatorcontrib>TERADA, Misao</creatorcontrib><creatorcontrib>ONO, Sadaharu</creatorcontrib><creatorcontrib>MURAKAMI, Akiyoshi</creatorcontrib><creatorcontrib>ISHIDA, Tomoko</creatorcontrib><creatorcontrib>SANO, Tadashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ONUMA, Mamoru</au><au>TERADA, Misao</au><au>ONO, Sadaharu</au><au>MURAKAMI, Akiyoshi</au><au>ISHIDA, Tomoko</au><au>SANO, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of anaphylactic reactions after propofol administration in dogs</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2017</date><risdate>2017</risdate><volume>79</volume><issue>8</issue><spage>1446</spage><epage>1452</epage><pages>1446-1452</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected. Following intravenous administration of propofol, the incidence of anaphylactic reactions and plasma histamine concentrations under general anesthesia maintained with isoflurane throughout surgery were compared between the two groups. The frequency of anaphylactic reactions and plasma histamine concentrations were compared by the chi-square test and Student t-test, respectively. The statistical significance for both tests was set at P<0.05. In the high- and normal-IgE groups, the average frequencies of anaphylactic reactions after propofol administration were 21.4 and 14.3%, and the mean plasma histamine concentrations were 167.9 ± 94.5 nM and 65.7 ± 40.3 nM, respectively. Animals of neither groups experienced shock-like symptoms. These results revealed that propofol might be relatively safe, although careful perioperative anesthesia monitoring and standby protocols are required when using propofol in dogs with a history of allergic diseases or high chicken- or soybean-specific IgE levels.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>28717055</pmid><doi>10.1292/jvms.16-0550</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anaphylaxis - chemically induced Anaphylaxis - veterinary anesthesia Anesthesia, General - adverse effects Anesthetics, Intravenous Animals dog Dog Diseases - chemically induced Dogs Egg Hypersensitivity Female histamine Hypnotics and Sedatives - adverse effects Immunoglobulin E - analysis immunoglobulin-E Incidence Lecithins - adverse effects Male Propofol - adverse effects propofol-induced anaphylaxis Retrospective Studies Soybean Oil - adverse effects Surgery |
| title | Incidence of anaphylactic reactions after propofol administration in dogs |
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