Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin β3 Signaling

Targeting angiogenesis has emerged as a promising strategy for cancer treatment. Methylseleninic acid (MSA) is a metabolite of selenium (Se) in animal cells that exhibits anti-oxidative and anti-cancer activities at levels exceeding Se nutritional requirements. However, it remains unclear whether MS...

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Veröffentlicht in:	Scientific reports 2017-08, Vol.7 (1), p.9445-13, Article 9445
Hauptverfasser:	Cai, Zhihui, Dong, Liangbo, Song, Chengwei, Zhang, Yanqing, Zhu, Chenghui, Zhang, Yibo, Ling, Qinjie, Hoffmann, Peter R., Li, Jun, Huang, Zhi, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 38 631/92/609 692/308/153 82 96 AKT protein Angiogenesis Angiogenesis Inducing Agents Animals Aorta Cancer Cancer therapies Cell Adhesion Cell adhesion & migration Cell migration Cell Movement Cell surface Chick Embryo Chorioallantoic membrane Chorioallantoic Membrane - blood supply Down-Regulation Endothelium, Vascular - drug effects Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Integrin beta3 - genetics Integrin beta3 - metabolism Metabolites mRNA multidisciplinary NF-kappa B - metabolism NF-κB protein Nutritional Physiological Phenomena Nutritional requirements Nutritional status Organoselenium Compounds - metabolism Organoselenium Compounds - pharmacology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Science Science (multidisciplinary) Selenium Selenium - metabolism Signal Transduction
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