Influence of Mitochondrial Genetics on the Mitochondrial Toxicity of Linezolid in Blood Cells and Skin Nerve Fibers

The antibiotic linezolid is a ribosomal inhibitor with excellent efficacy. Although the administration period has been reduced to 28 days, side effects, usually of hematologic or neuropathic origin, are still reported due to secondary inhibition of mitochondrial protein synthesis. Susceptibility to...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-09, Vol.61 (9)
Hauptverfasser:	Garrabou, G, Soriano, À, Pinós, T, Casanova-Mollà, J, Pacheu-Grau, D, Morén, C, García-Arumí, E, Morales, M, Ruiz-Pesini, E, Catalán-Garcia, M, Milisenda, J C, Lozano, E, Andreu, A L, Montoya, J, Mensa, J, Cardellach, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anti-Bacterial Agents Anti-Bacterial Agents - toxicity Cyclooxygenase 2 Cyclooxygenase 2 - metabolism Electron Transport Complex IV - metabolism Female Humans Leukocytes, Mononuclear Leukocytes, Mononuclear - drug effects Linezolid Linezolid - toxicity Male Middle Aged Mitochondria Mitochondria - drug effects Mitochondria - genetics Mitochondrial Proteins - metabolism Nerve Fibers Nerve Fibers - drug effects Polymorphism, Single Nucleotide - genetics Protein Synthesis Inhibitors Protein Synthesis Inhibitors - toxicity RNA, Ribosomal - genetics RNA, Ribosomal, 16S - genetics Skin - cytology Skin - innervation Susceptibility Voltage-Dependent Anion Channels Voltage-Dependent Anion Channels - metabolism
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