Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition

The peptide drug enfuvirtide (T20) is the only viral fusion inhibitor used in combination therapy for HIV-1 infection, but it has relatively low antiviral activity and easily induces drug resistance. Emerging studies demonstrate that lipopeptide-based fusion inhibitors, such as LP-11 and LP-19, whic...

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Veröffentlicht in:	Journal of virology 2017-09, Vol.91 (18)
Hauptverfasser:	Ding, Xiaohui, Zhang, Xiujuan, Chong, Huihui, Zhu, Yuanmei, Wei, Huamian, Wu, Xiyuan, He, Jinsheng, Wang, Xinquan, He, Yuxian
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray HIV - drug effects HIV Envelope Protein gp41 - pharmacology HIV Fusion Inhibitors - chemistry HIV Fusion Inhibitors - isolation & purification HIV Fusion Inhibitors - pharmacology Lipopeptides - chemistry Lipopeptides - isolation & purification Lipopeptides - pharmacology Peptide Fragments - pharmacology Protein Binding Vaccines and Antiviral Agents Virus Internalization - drug effects
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