Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

The developing human cortex contains diverse populations of neural progenitor cells, including a large proportion of outer radial glia (ORG), a progenitor type that is rare in the mouse. The authors identify a transcriptional signature of ORG characterized by markers of neuronal lineage fate and use...

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Veröffentlicht in:	Nature neuroscience 2015-05, Vol.18 (5), p.637-646
Hauptverfasser:	Johnson, Matthew B, Wang, Peter P, Atabay, Kutay D, Murphy, Elisabeth A, Doan, Ryan N, Hecht, Jonathan L, Walsh, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 631/378/2571/2579 631/378/2571/2580 631/553/2706 Animal Genetics and Genomics Animals Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - genetics Behavioral Sciences Biological Techniques Biomedicine Brain research Cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Ependymoglial Cells - metabolism Ferrets Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Genetic aspects Genetic research Genetic transcription Humans Mice Molecular Sequence Data Mustela putorius furo Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neural Stem Cells - metabolism Neurobiology Neurogenesis Neurosciences RNA, Long Noncoding - genetics Sequence Alignment Sequence Analysis, RNA Sequence Homology, Nucleic Acid Single-Cell Analysis Species Specificity Transcription factors Transcription, Genetic
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