Utilizing Paper‐Based Devices for Antimicrobial‐Resistant Bacteria Detection
Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted t...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2017-06, Vol.56 (24), p.6886-6890 |
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| creator | Boehle, Katherine E. Gilliand, Jake Wheeldon, Christopher R. Holder, Amethyst Adkins, Jaclyn A. Geiss, Brian J. Ryan, Elizabeth P. Henry, Charles S. |
| description | Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper‐based analytical devices (PADs) that can test for the presence of β‐lactamase‐mediated resistance. To demonstrate viability, the PAD was used to detect β‐lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources.
Resistance is futile: Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise because of the widespread use of antimicrobial agents. An inexpensive, fast assay using a paper‐based analytical device (PAD) has been developed to monitor water sources for the presence of β‐lactamase‐mediated resistance. |
| doi_str_mv | 10.1002/anie.201702776 |
| format | Article |
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Resistance is futile: Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise because of the widespread use of antimicrobial agents. An inexpensive, fast assay using a paper‐based analytical device (PAD) has been developed to monitor water sources for the presence of β‐lactamase‐mediated resistance.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201702776</identifier><identifier>PMID: 28474847</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Amides ; Anti-Bacterial Agents - pharmacology ; Antiinfectives and antibacterials ; Antimicrobial agents ; Antimicrobial resistance ; Assaying ; Bacteria ; Bacteria - classification ; Bacteria - drug effects ; Bacteria - growth & development ; Bacteria - isolation & purification ; beta-Lactam Resistance ; beta-Lactamase Inhibitors - pharmacology ; Colony Count, Microbial ; Colorimetry ; Contamination ; Death ; Devices ; Electrochemical Techniques ; Environmental monitoring ; Microbiological Techniques ; nitrocefin ; paper-based analytical devices ; Reproducibility of Results ; Sewage ; Sewage - microbiology ; Sewers ; Viability ; Waste Water - microbiology ; Wastewater ; Water Microbiology ; Water pollution ; β-lactam antibiotics ; β-lactamase</subject><ispartof>Angewandte Chemie International Edition, 2017-06, Vol.56 (24), p.6886-6890</ispartof><rights>2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5056-796748a572962dba095de5b8ba18de1cb4f8ea0d49157bde465ce267b39bff353</citedby><cites>FETCH-LOGICAL-c5056-796748a572962dba095de5b8ba18de1cb4f8ea0d49157bde465ce267b39bff353</cites><orcidid>0000-0002-8671-7728</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201702776$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201702776$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28474847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boehle, Katherine E.</creatorcontrib><creatorcontrib>Gilliand, Jake</creatorcontrib><creatorcontrib>Wheeldon, Christopher R.</creatorcontrib><creatorcontrib>Holder, Amethyst</creatorcontrib><creatorcontrib>Adkins, Jaclyn A.</creatorcontrib><creatorcontrib>Geiss, Brian J.</creatorcontrib><creatorcontrib>Ryan, Elizabeth P.</creatorcontrib><creatorcontrib>Henry, Charles S.</creatorcontrib><title>Utilizing Paper‐Based Devices for Antimicrobial‐Resistant Bacteria Detection</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper‐based analytical devices (PADs) that can test for the presence of β‐lactamase‐mediated resistance. To demonstrate viability, the PAD was used to detect β‐lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources.
Resistance is futile: Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise because of the widespread use of antimicrobial agents. An inexpensive, fast assay using a paper‐based analytical device (PAD) has been developed to monitor water sources for the presence of β‐lactamase‐mediated resistance.</description><subject>Amides</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Assaying</subject><subject>Bacteria</subject><subject>Bacteria - classification</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - growth & development</subject><subject>Bacteria - isolation & purification</subject><subject>beta-Lactam Resistance</subject><subject>beta-Lactamase Inhibitors - pharmacology</subject><subject>Colony Count, Microbial</subject><subject>Colorimetry</subject><subject>Contamination</subject><subject>Death</subject><subject>Devices</subject><subject>Electrochemical Techniques</subject><subject>Environmental monitoring</subject><subject>Microbiological Techniques</subject><subject>nitrocefin</subject><subject>paper-based analytical devices</subject><subject>Reproducibility of Results</subject><subject>Sewage</subject><subject>Sewage - microbiology</subject><subject>Sewers</subject><subject>Viability</subject><subject>Waste Water - microbiology</subject><subject>Wastewater</subject><subject>Water Microbiology</subject><subject>Water pollution</subject><subject>β-lactam antibiotics</subject><subject>β-lactamase</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAYRoMo3rcupeC6Yy7NpRthHK8gKqLrkLR_NdJpxySj6MpH8Bl9EiOjo65chARycvIlH0JbBA8IxnTXdA4GFBOJqZRiAa0STknOpGSLaV0wlkvFyQpaC-E-8UphsYxWqCpkkcYquryJrnUvrrvNLs0E_Pvr274JUGcH8OgqCFnT-2zYRTd2le-tM20iriC4EE0Xs31TRfDOJDxCFV3fbaClxrQBNr_mdXRzdHg9OsnPLo5PR8OzvOKYi1yWIiUwXNJS0NoaXPIauFXWEFUDqWzRKDC4LkrCpa2hELwCKqRlpW0axtk62pt5J1M7hrqCLnrT6ol3Y-OfdW-c_rvTuTt92z9qzoVSQiTBzpfA9w9TCFHf91PfpcyalLggjFHGEjWYUen1IXho5jcQrD8b0J8N6HkD6cD271xz_PvLE1DOgCfXwvM_Oj08Pz38kX8A0lmWTQ</recordid><startdate>20170606</startdate><enddate>20170606</enddate><creator>Boehle, Katherine E.</creator><creator>Gilliand, Jake</creator><creator>Wheeldon, Christopher R.</creator><creator>Holder, Amethyst</creator><creator>Adkins, Jaclyn A.</creator><creator>Geiss, Brian J.</creator><creator>Ryan, Elizabeth P.</creator><creator>Henry, Charles S.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8671-7728</orcidid></search><sort><creationdate>20170606</creationdate><title>Utilizing Paper‐Based Devices for Antimicrobial‐Resistant Bacteria Detection</title><author>Boehle, Katherine E. ; Gilliand, Jake ; Wheeldon, Christopher R. ; Holder, Amethyst ; Adkins, Jaclyn A. ; Geiss, Brian J. ; Ryan, Elizabeth P. ; Henry, Charles S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5056-796748a572962dba095de5b8ba18de1cb4f8ea0d49157bde465ce267b39bff353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amides</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial resistance</topic><topic>Assaying</topic><topic>Bacteria</topic><topic>Bacteria - classification</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - growth & development</topic><topic>Bacteria - isolation & purification</topic><topic>beta-Lactam Resistance</topic><topic>beta-Lactamase Inhibitors - pharmacology</topic><topic>Colony Count, Microbial</topic><topic>Colorimetry</topic><topic>Contamination</topic><topic>Death</topic><topic>Devices</topic><topic>Electrochemical Techniques</topic><topic>Environmental monitoring</topic><topic>Microbiological Techniques</topic><topic>nitrocefin</topic><topic>paper-based analytical devices</topic><topic>Reproducibility of Results</topic><topic>Sewage</topic><topic>Sewage - microbiology</topic><topic>Sewers</topic><topic>Viability</topic><topic>Waste Water - microbiology</topic><topic>Wastewater</topic><topic>Water Microbiology</topic><topic>Water pollution</topic><topic>β-lactam antibiotics</topic><topic>β-lactamase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boehle, Katherine E.</creatorcontrib><creatorcontrib>Gilliand, Jake</creatorcontrib><creatorcontrib>Wheeldon, Christopher R.</creatorcontrib><creatorcontrib>Holder, Amethyst</creatorcontrib><creatorcontrib>Adkins, Jaclyn A.</creatorcontrib><creatorcontrib>Geiss, Brian J.</creatorcontrib><creatorcontrib>Ryan, Elizabeth P.</creatorcontrib><creatorcontrib>Henry, Charles S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boehle, Katherine E.</au><au>Gilliand, Jake</au><au>Wheeldon, Christopher R.</au><au>Holder, Amethyst</au><au>Adkins, Jaclyn A.</au><au>Geiss, Brian J.</au><au>Ryan, Elizabeth P.</au><au>Henry, Charles S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utilizing Paper‐Based Devices for Antimicrobial‐Resistant Bacteria Detection</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2017-06-06</date><risdate>2017</risdate><volume>56</volume><issue>24</issue><spage>6886</spage><epage>6890</epage><pages>6886-6890</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper‐based analytical devices (PADs) that can test for the presence of β‐lactamase‐mediated resistance. To demonstrate viability, the PAD was used to detect β‐lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources.
Resistance is futile: Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise because of the widespread use of antimicrobial agents. An inexpensive, fast assay using a paper‐based analytical device (PAD) has been developed to monitor water sources for the presence of β‐lactamase‐mediated resistance.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28474847</pmid><doi>10.1002/anie.201702776</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-8671-7728</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amides Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Antimicrobial agents Antimicrobial resistance Assaying Bacteria Bacteria - classification Bacteria - drug effects Bacteria - growth & development Bacteria - isolation & purification beta-Lactam Resistance beta-Lactamase Inhibitors - pharmacology Colony Count, Microbial Colorimetry Contamination Death Devices Electrochemical Techniques Environmental monitoring Microbiological Techniques nitrocefin paper-based analytical devices Reproducibility of Results Sewage Sewage - microbiology Sewers Viability Waste Water - microbiology Wastewater Water Microbiology Water pollution β-lactam antibiotics β-lactamase |
| title | Utilizing Paper‐Based Devices for Antimicrobial‐Resistant Bacteria Detection |
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