Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors

Andexanet alfa, a catalytically inactive decoy of factor Xa, successfully reversed the factor Xa inhibitory effects of rivaroxaban and apixaban in a small study involving patients with acute major bleeding. In randomized clinical trials, factor Xa inhibitors have been shown to be safe and effective...

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Veröffentlicht in:	The New England journal of medicine 2016-09, Vol.375 (12), p.1131-1141
Hauptverfasser:	Connolly, Stuart J, Milling, Truman J, Eikelboom, John W, Gibson, C. Michael, Curnutte, John T, Gold, Alex, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Goodman, Shelly, Leeds, Janet, Wiens, Brian L, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Nakamya, Juliet, Lim, W. Ting, Crowther, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged Aged, 80 and over Bleeding Cardiovascular diseases Cardiovascular Diseases - complications Coagulation Drug therapy Enoxaparin - adverse effects Enzymes Factor Xa - adverse effects Factor Xa - therapeutic use Factor Xa Inhibitors - adverse effects Factor Xa Inhibitors - metabolism Factor Xa Inhibitors - therapeutic use Female Gastrointestinal Hemorrhage - chemically induced Gastrointestinal Hemorrhage - drug therapy Hemorrhage Hemorrhage - chemically induced Hemorrhage - drug therapy Hemostasis Humans Infusions, Intravenous Intracranial Hemorrhages - chemically induced Intracranial Hemorrhages - diagnosis Intracranial Hemorrhages - drug therapy Male Prospective Studies Pyrazoles - adverse effects Pyridones - adverse effects Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Rivaroxaban - adverse effects Thrombosis - etiology
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