Increases from 2002 to 2015 in prescription opioid overdose deaths in combination with other substances

•22% of increased prescription opioid (PO) deaths are attributable to 5 other drugs.•Benzodiazepines and heroin contribute equally to increased PO deaths.•Heroin contributes most to increased PO deaths at ages 18–49, among males, whites.•Increased non-methadone synthetic opioid deaths are mostly att...

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