Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells

In the adult brain, programmed death of neural stem cells is considered to be critical for tissue homeostasis and cognitive function and is dysregulated in neurodegeneration. Previously, we have reported that adult rat hippocampal neural (HCN) stem cells undergo autophagic cell death (ACD) following...

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Veröffentlicht in:	The Journal of biological chemistry 2017-08, Vol.292 (33), p.13795-13808
Hauptverfasser:	Ha, Shinwon, Jeong, Seol-Hwa, Yi, Kyungrim, Chung, Kyung Min, Hong, Caroline Jeeyeon, Kim, Seong Who, Kim, Eun-Kyoung, Yu, Seong-Woon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - drug effects Adult Stem Cells - metabolism Amino Acid Substitution AMP-activated kinase (AMPK) AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - chemistry AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals autophagy Autophagy - drug effects Autophagy-Related Protein 7 - antagonists & inhibitors Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Cell Survival - drug effects Cells, Cultured Enzyme Activation - drug effects Gene Deletion Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Humans mitophagy Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural Stem Cells - cytology Neural Stem Cells - drug effects Neural Stem Cells - metabolism p62 (sequestosome 1 (SQSTM1)) phosphorylation Phosphorylation - drug effects Point Mutation Protein Kinase Inhibitors - pharmacology Protein Processing, Post-Translational - drug effects Protein Synthesis and Degradation Protein Transport - drug effects Rats Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism RNA Interference Sequestosome-1 Protein - antagonists & inhibitors Sequestosome-1 Protein - genetics Sequestosome-1 Protein - metabolism
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