Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2

The human p68 kinase is an interferon‐regulated enzyme that inhibits protein synthesis when activated by double‐stranded RNA. We show here that when expressed in Saccharomyces cerevisiae, the p68 kinase produced a growth suppressing phenotype resulting from an inhibition of polypeptide chain initiat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 1992-04, Vol.11 (4), p.1553-1562
Hauptverfasser:	Chong, K.L., Feng, L., Schappert, K., Meurs, E., Donahue, T.F., Friesen, J.D., Hovanessian, A.G., Williams, B.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences DNA-Binding Proteins - genetics eIF-2 Kinase Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Gene Expression Regulation, Fungal Humans Molecular and cellular biology Molecular genetics Molecular Sequence Data Oligodeoxyribonucleotides Plasmids Polyribosomes - enzymology Protein Kinases - genetics Protein Kinases - metabolism Recombinant Proteins - metabolism Restriction Mapping Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins Sequence Homology, Nucleic Acid Suppression, Genetic Transcription Factors - genetics Translation. Translation factors. Protein processing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!