Pharmacodynamics of the Orotomides against Aspergillus fumigatus : New Opportunities for Treatment of Multidrug-Resistant Fungal Disease

F901318 is an antifungal agent with a novel mechanism of action and potent activity against spp. An understanding of the pharmacodynamics (PD) of F901318 is required for selection of effective regimens for study in phase II and III clinical trials. Neutropenic murine and rabbit models of invasive pu...

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Veröffentlicht in:	mBio 2017-08, Vol.8 (4)
Hauptverfasser:	Hope, William W, McEntee, Laura, Livermore, Joanne, Whalley, Sarah, Johnson, Adam, Farrington, Nicola, Kolamunnage-Dona, Ruwanthi, Schwartz, Julie, Kennedy, Anthony, Law, Derek, Birch, Michael, Rex, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacokinetics Acetamides - pharmacology Acetamides - therapeutic use Acetamides - toxicity Animals Antifungal Agents - pharmacokinetics Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antifungal Agents - toxicity Aspergillus fumigatus - drug effects Disease Models, Animal Drug Discovery Drug Resistance, Multiple, Fungal Invasive Pulmonary Aspergillosis - drug therapy Invasive Pulmonary Aspergillosis - microbiology Mannans - blood Mice Microbial Sensitivity Tests Neutropenia Piperazines - pharmacokinetics Piperazines - pharmacology Piperazines - therapeutic use Piperazines - toxicity Pneumonia - drug therapy Pneumonia - microbiology Pyrimidines - pharmacokinetics Pyrimidines - pharmacology Pyrimidines - therapeutic use Pyrimidines - toxicity Pyrroles - pharmacokinetics Pyrroles - pharmacology Pyrroles - therapeutic use Pyrroles - toxicity Rabbits Triazoles - administration & dosage Triazoles - pharmacokinetics Triazoles - pharmacology Triazoles - therapeutic use
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