Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines

We have previously reported that certain genes of the HOX2 cluster of homeobox genes on human chromosome 17 are specifically expressed in human leukemic cell lines with erythroid potential, suggesting that these genes are involved in hematopoietic differentiation. We now show that the expression of...

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Veröffentlicht in:	The EMBO journal 1992-03, Vol.11 (3), p.983-989
Hauptverfasser:	Shen, W.F., Detmer, K., Mathews, C.H., Hack, F.M., Morgan, D.A., Largman, C., Lawrence, H.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Northern Cell Differentiation Chromosomes, Human, Pair 17 Fundamental and applied biological sciences. Psychology Gene Expression Genes, Homeobox Genetic Vectors Globins - genetics Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hematopoietic Stem Cells - cytology Heme - metabolism Humans Leukemia - genetics Leukemia - metabolism Molecular and cellular biology Molecular genetics Phenotype RNA - genetics Transcription, Genetic Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
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