Mechanisms of Cognitive Aging in the HIV-Positive Adult
Purpose of Review As of the year 2016, an estimated 50% of the US HIV-positive population is aged 50 years or older. Due to a combination of increased rates of infection in older adults, and successful anti-retroviral (ART) regimens allowing HIV-positive adults to survive for decades with the diseas...
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| Veröffentlicht in: | Current behavioral neuroscience reports 2017-09, Vol.4 (3), p.188-197 |
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| creator | Kamkwalala, Asante Newhouse, Paul |
| description | Purpose of Review
As of the year 2016, an estimated 50% of the US HIV-positive population is aged 50 years or older. Due to a combination of increased rates of infection in older adults, and successful anti-retroviral (ART) regimens allowing HIV-positive adults to survive for decades with the disease, we are now faced with a steadily graying HIV-positive population, with only limited knowledge of how the cognitive and physiological effects of aging intersect with those of chronic HIV infection.
Recent Findings
Age-related changes to mood, cognition, and neurological health may be experienced differently in those living with HIV, and research concerning quality of life, mental health, and cognitive aging needs to account for and explore these factors more carefully in the coming years.
Summary
This review will explore the topic of cognitive aging with HIV: (1) central nervous system (CNS) infection of HIV and how the virus affects brain integrity and function; (2) cognitive and behavioral symptoms of HIV-associated neurocognitive disorders (HAND); (3) neurobiological theories of cognitive aging and how these processes may be exacerbated by HIV infection; and (4) clinical implications and complications of aging with HIV and factors that may result in poorer cognitive outcomes. |
| doi_str_mv | 10.1007/s40473-017-0122-9 |
| format | Article |
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As of the year 2016, an estimated 50% of the US HIV-positive population is aged 50 years or older. Due to a combination of increased rates of infection in older adults, and successful anti-retroviral (ART) regimens allowing HIV-positive adults to survive for decades with the disease, we are now faced with a steadily graying HIV-positive population, with only limited knowledge of how the cognitive and physiological effects of aging intersect with those of chronic HIV infection.
Recent Findings
Age-related changes to mood, cognition, and neurological health may be experienced differently in those living with HIV, and research concerning quality of life, mental health, and cognitive aging needs to account for and explore these factors more carefully in the coming years.
Summary
This review will explore the topic of cognitive aging with HIV: (1) central nervous system (CNS) infection of HIV and how the virus affects brain integrity and function; (2) cognitive and behavioral symptoms of HIV-associated neurocognitive disorders (HAND); (3) neurobiological theories of cognitive aging and how these processes may be exacerbated by HIV infection; and (4) clinical implications and complications of aging with HIV and factors that may result in poorer cognitive outcomes.</description><identifier>ISSN: 2196-2979</identifier><identifier>EISSN: 2196-2979</identifier><identifier>DOI: 10.1007/s40473-017-0122-9</identifier><identifier>PMID: 28840088</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Aging ; Alzheimer's disease ; Asymptomatic ; Behavioral Therapy ; Biomarkers ; Blood-brain barrier ; Chemokines ; Cognition & reasoning ; Cognitive ability ; Geropsychiatry & Cognitive Disorders of Late Life (P Newhouse ; HIV ; Human immunodeficiency virus ; Infections ; Medicine ; Medicine & Public Health ; Memory ; Nervous system ; Neurodegeneration ; Neurology ; Pediatrics ; Psychiatry ; Section Editor ; Topical Collection on Geropsychiatry & Cognitive Disorders of Late Life</subject><ispartof>Current behavioral neuroscience reports, 2017-09, Vol.4 (3), p.188-197</ispartof><rights>Springer International Publishing AG 2017</rights><rights>Springer International Publishing AG 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3859-848fbc606692ebd881e3eac2456fbb2fbb7940dbe97beb642fead71a00d797223</citedby><cites>FETCH-LOGICAL-c3859-848fbc606692ebd881e3eac2456fbb2fbb7940dbe97beb642fead71a00d797223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40473-017-0122-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40473-017-0122-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28840088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamkwalala, Asante</creatorcontrib><creatorcontrib>Newhouse, Paul</creatorcontrib><title>Mechanisms of Cognitive Aging in the HIV-Positive Adult</title><title>Current behavioral neuroscience reports</title><addtitle>Curr Behav Neurosci Rep</addtitle><addtitle>Curr Behav Neurosci Rep</addtitle><description>Purpose of Review
As of the year 2016, an estimated 50% of the US HIV-positive population is aged 50 years or older. Due to a combination of increased rates of infection in older adults, and successful anti-retroviral (ART) regimens allowing HIV-positive adults to survive for decades with the disease, we are now faced with a steadily graying HIV-positive population, with only limited knowledge of how the cognitive and physiological effects of aging intersect with those of chronic HIV infection.
Recent Findings
Age-related changes to mood, cognition, and neurological health may be experienced differently in those living with HIV, and research concerning quality of life, mental health, and cognitive aging needs to account for and explore these factors more carefully in the coming years.
Summary
This review will explore the topic of cognitive aging with HIV: (1) central nervous system (CNS) infection of HIV and how the virus affects brain integrity and function; (2) cognitive and behavioral symptoms of HIV-associated neurocognitive disorders (HAND); (3) neurobiological theories of cognitive aging and how these processes may be exacerbated by HIV infection; and (4) clinical implications and complications of aging with HIV and factors that may result in poorer cognitive outcomes.</description><subject>Age</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Asymptomatic</subject><subject>Behavioral Therapy</subject><subject>Biomarkers</subject><subject>Blood-brain barrier</subject><subject>Chemokines</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Geropsychiatry & Cognitive Disorders of Late Life (P Newhouse</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Infections</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory</subject><subject>Nervous system</subject><subject>Neurodegeneration</subject><subject>Neurology</subject><subject>Pediatrics</subject><subject>Psychiatry</subject><subject>Section Editor</subject><subject>Topical Collection on Geropsychiatry & Cognitive Disorders of Late Life</subject><issn>2196-2979</issn><issn>2196-2979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kUFr3DAQhUVpaEKyP6CXYuilF6ejsWxJl0JY0iawITkkvQrZHnsVvFJi2Qv991XYTZoGchgkeN-8meEx9pnDKQeQ36MAIYscuEyFmOsP7Ai5rnLUUn989T9kixjvAYBzAbxUn9ghKiUAlDpi8oqatfUubmIWumwZeu8mt6XsrHe-z5zPpjVlF5e_85sQ90o7D9MJO-jsEGmxf4_Z3c_z2-VFvrr-dbk8W-VNoUqdK6G6uqmgqjRS3SrFqSDboCirrq4xldQC2pq0rKmuBHZkW8ktQCu1RCyO2Y-d78Ncb6htyE-jHczD6DZ2_GOCdeZ_xbu16cPWlGVVIqpk8G1vMIbHmeJkNi42NAzWU5ij4bpAJTCtmNCvb9D7MI8-nWdQgQBVClEmiu-oZgwxjtS9LMPBPCVjdsmYlIx5Ssbo1PPl9RUvHc85JAB3QEyS72n8N_p9178mhpfO</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Kamkwalala, Asante</creator><creator>Newhouse, Paul</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Mechanisms of Cognitive Aging in the HIV-Positive Adult</title><author>Kamkwalala, Asante ; Newhouse, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3859-848fbc606692ebd881e3eac2456fbb2fbb7940dbe97beb642fead71a00d797223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Asymptomatic</topic><topic>Behavioral Therapy</topic><topic>Biomarkers</topic><topic>Blood-brain barrier</topic><topic>Chemokines</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Geropsychiatry & Cognitive Disorders of Late Life (P Newhouse</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Infections</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Memory</topic><topic>Nervous system</topic><topic>Neurodegeneration</topic><topic>Neurology</topic><topic>Pediatrics</topic><topic>Psychiatry</topic><topic>Section Editor</topic><topic>Topical Collection on Geropsychiatry & Cognitive Disorders of Late Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamkwalala, Asante</creatorcontrib><creatorcontrib>Newhouse, Paul</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current behavioral neuroscience reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamkwalala, Asante</au><au>Newhouse, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of Cognitive Aging in the HIV-Positive Adult</atitle><jtitle>Current behavioral neuroscience reports</jtitle><stitle>Curr Behav Neurosci Rep</stitle><addtitle>Curr Behav Neurosci Rep</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>4</volume><issue>3</issue><spage>188</spage><epage>197</epage><pages>188-197</pages><issn>2196-2979</issn><eissn>2196-2979</eissn><abstract>Purpose of Review
As of the year 2016, an estimated 50% of the US HIV-positive population is aged 50 years or older. Due to a combination of increased rates of infection in older adults, and successful anti-retroviral (ART) regimens allowing HIV-positive adults to survive for decades with the disease, we are now faced with a steadily graying HIV-positive population, with only limited knowledge of how the cognitive and physiological effects of aging intersect with those of chronic HIV infection.
Recent Findings
Age-related changes to mood, cognition, and neurological health may be experienced differently in those living with HIV, and research concerning quality of life, mental health, and cognitive aging needs to account for and explore these factors more carefully in the coming years.
Summary
This review will explore the topic of cognitive aging with HIV: (1) central nervous system (CNS) infection of HIV and how the virus affects brain integrity and function; (2) cognitive and behavioral symptoms of HIV-associated neurocognitive disorders (HAND); (3) neurobiological theories of cognitive aging and how these processes may be exacerbated by HIV infection; and (4) clinical implications and complications of aging with HIV and factors that may result in poorer cognitive outcomes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28840088</pmid><doi>10.1007/s40473-017-0122-9</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Current behavioral neuroscience reports, 2017-09, Vol.4 (3), p.188-197 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Age Aging Alzheimer's disease Asymptomatic Behavioral Therapy Biomarkers Blood-brain barrier Chemokines Cognition & reasoning Cognitive ability Geropsychiatry & Cognitive Disorders of Late Life (P Newhouse HIV Human immunodeficiency virus Infections Medicine Medicine & Public Health Memory Nervous system Neurodegeneration Neurology Pediatrics Psychiatry Section Editor Topical Collection on Geropsychiatry & Cognitive Disorders of Late Life |
| title | Mechanisms of Cognitive Aging in the HIV-Positive Adult |
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