Activation of extracellular signal‐regulated kinase, ERK2, by p21ras oncoprotein

To examine signal transduction events activated by oncogenic p21ras, we have studied kinases that are activated following the scrape loading of p21ras into quiescent cells. We observe rapid activation of 42 kDa and 46 kDa protein kinases. The 42 kDa kinase is the mitogen and extracellular‐signal reg...

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Veröffentlicht in:	The EMBO journal 1992-02, Vol.11 (2), p.569-574
Hauptverfasser:	Leevers, S.J., Marshall, C.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells activation Amino Acid Sequence Animals Biological and medical sciences Blotting, Western Calcium-Calmodulin-Dependent Protein Kinases Cell Line, Transformed Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Enzyme Activation ERK2 protein Flow Cytometry Fundamental and applied biological sciences. Psychology Kinetics Mice Mitogen-Activated Protein Kinase 1 Molecular and cellular biology Molecular Sequence Data pathways Phosphates - metabolism Phosphorylation Phosphotyrosine protein kinase protein p21 Protein-Tyrosine Kinases - metabolism Proteins - isolation & purification Proteins - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - isolation & purification Proto-Oncogene Proteins p21(ras) - metabolism ras ras protein Recombinant Proteins - metabolism Signal Transduction Tyrosine - analogs & derivatives
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