Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons

Cytochrome c can acquire peroxidase activity when it binds to cardiolipin in mitochondrial membranes. The resulting oxygenation of cardiolipin by cytochrome c provides an early signal for the onset of apoptosis. The structure of this enzyme–substrate complex is a matter of considerable debate. We pr...

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Veröffentlicht in:	Journal of the American Chemical Society 2016-12, Vol.138 (51), p.16770-16778
Hauptverfasser:	McClelland, Levi J, Steele, Harmen B. B, Whitby, Frank G, Mou, Tung-Chung, Holley, David, Ross, J. B. Alexander, Sprang, Stephen R, Bowler, Bruce E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cytochromes c - chemistry Cytochromes c - metabolism Detergents - metabolism Enzyme Stability Horses Hydrocarbons - metabolism Linoleic Acid - metabolism Molecular Docking Simulation Protein Domains Protein Multimerization Protein Structure, Quaternary Surface Properties
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