Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy

Abstract Implantable neural electrode technologies for chronic neural recordings can restore functional control to paralysis and limb loss victims through brain-machine interfaces. These probes, however, have high failure rates partly due to the biological responses to the probe which generates an i...

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Veröffentlicht in:	Biomaterials 2017-01, Vol.113, p.279-292
Hauptverfasser:	Eles, James, Vazquez, Alberto L, Snyder, Noah R, Lagenaur, Carl, Murphy, Matthew C, Kozai, Takashi D.Y, Cui, X. Tracy
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Advanced Basic Science Animals Biomimetic coatings Cell Adhesion cell death Coated Materials, Biocompatible - adverse effects Coated Materials, Biocompatible - chemistry Coating coatings cortex Dentistry Electrodes Electrodes, Implanted - adverse effects Foreign body response Foreign-Body Reaction - etiology Foreign-Body Reaction - prevention & control Immobilized Proteins - adverse effects Immobilized Proteins - chemistry mechanism of action Mice Mice, Transgenic Microelectrode implants Microelectrodes - adverse effects Microglia - cytology Microglia - physiology Microglia - ultrastructure Microscopy Neural camouflage Neural Cell Adhesion Molecule L1 - adverse effects Neural Cell Adhesion Molecule L1 - chemistry neuroglia neurons paralysis Protein immobilization Scars Surface chemistry Surface modification Surgical implants
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