Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes

CD79a and CD79b proteins associate with Ig receptors as integral signaling components of the B cell Ag receptor complex. To study B cell development in zebrafish, we isolated orthologs of these genes and performed in situ hybridization, finding that their expression colocalized with IgH-μ in the kid...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-09, Vol.199 (5), p.1706-1715
Hauptverfasser:	Liu, Xingjun, Li, Yue-Sheng, Shinton, Susan A, Rhodes, Jennifer, Tang, Lingjuan, Feng, Hui, Jette, Cicely A, Look, A Thomas, Hayakawa, Kyoko, Hardy, Richard R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified B-cell receptor B-Lymphocytes - physiology CD79 Antigens - genetics CD79 Antigens - metabolism Cell Differentiation Cloning, Molecular Danio rerio Developmental stages DNA-Binding Proteins - genetics Fish Proteins - genetics Fish Proteins - metabolism Fluorescence Genes, Reporter - genetics Green Fluorescent Proteins - genetics Heavy chains Immune System Development Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - metabolism Immunoglobulins Kidney - physiology Lymphocyte Activation Lymphocyte receptors Lymphocytes B Mammals Precursor Cells, B-Lymphoid - physiology Proteins RAG1 protein RAG2 protein Recombination Transgenes Transgenes - genetics Zebrafish - immunology Zebrafish Proteins - genetics
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