β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching

Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide confo...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-11, Vol.51 (90), p.16259-16262
Hauptverfasser:	Kang, Chang Won, Sarnowski, Matthew P, Ranatunga, Sujeewa, Wojtas, Lukasz, Metcalf, Rainer S, Guida, Wayne C, Del Valle, Juan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetic Materials - chemical synthesis Biomimetic Materials - chemistry Covalence Crystallography, X-Ray Flexibility Models, Molecular Molecular Conformation Peptides Peptides - chemistry Pyridazines - chemistry Stabilization Stitching Synthesis Tethers X-rays
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