Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α

Whether the effect of miR-181a is sexually dimorphic in stroke is unknown. Prior work showed protection of male mice with miR-181a inhibition. Estrogen receptor-α (ERα) is an identified target of miR181 in endometrium. Therefore we investigated the separate and joint effects of miR-181a inhibition a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular neuroscience 2017-07, Vol.82, p.118-125
Hauptverfasser:	Stary, Creed M., Xu, Lijun, Li, Le, Sun, Xiaoyun, Ouyang, Yi-Bing, Xiong, Xiaoxing, Zhao, Jing, Giffard, Rona G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte Astrocytes - drug effects Astrocytes - metabolism Brain Ischemia - genetics Brain Ischemia - metabolism Disease Models, Animal Estrogen Estrogen Receptor alpha - genetics Female Ischemia-reperfusion injury Ischemic Attack, Transient - genetics Ischemic Attack, Transient - metabolism Male MCAO Mice, Inbred C57BL MicroRNA MicroRNAs - genetics Neurons - metabolism Neuroprotective Agents - pharmacology Reperfusion Injury - genetics Reperfusion Injury - metabolism Sex Factors Stroke
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!