N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability

Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively). 4-Methylamphetamine (4-MA) is an emerging drug of abuse that interacts with transporters, bu...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2017-09, Vol.42 (10), p.1950-1961
Hauptverfasser:	Solis, Jr, Ernesto, Partilla, John S, Sakloth, Farhana, Ruchala, Iwona, Schwienteck, Kathryn L, De Felice, Louis J, Eltit, Jose M, Glennon, Richard A, Negus, S Stevens, Baumann, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Amphetamine-Related Disorders - metabolism Amphetamines - administration & dosage Amphetamines - pharmacology Analogs Animals Brain Brain - drug effects Brain - metabolism Calcium Calcium - metabolism Calcium channels Calcium channels (voltage-gated) Calcium Channels - metabolism Calcium influx Depolarization Dopamine - metabolism Dopamine transporter Drug abuse HEK293 Cells Humans Intracranial self-stimulation Liability Male Membrane Potentials - drug effects Membrane Transport Modulators - administration & dosage Membrane Transport Modulators - pharmacology Monoamine transporter Norepinephrine Norepinephrine - metabolism Oocytes Original Rats Rats, Sprague-Dawley Rodents Self-stimulation Serotonin Serotonin - metabolism Serotonin transporter Stimulation Substrates Synaptosomes Synaptosomes - drug effects Synaptosomes - metabolism Vesicular Monoamine Transport Proteins - metabolism Xenopus laevis
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