Heat-Induced Calcium Leakage Causes Mitochondrial Damage in Caenorhabditis elegans Body-Wall Muscles

Acute onset of organ failure in heatstroke is triggered by rhabdomyolysis of skeletal muscle. Here, we showed that elevated temperature increases free cytosolic Ca [Ca ]f from RYR (ryanodine receptor)/UNC-68 in the muscles of an experimental model animal, the nematode This subsequently leads to mito...

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Veröffentlicht in:	Genetics (Austin) 2017-08, Vol.206 (4), p.1985-1994
Hauptverfasser:	Momma, Kenta, Homma, Takashi, Isaka, Ruri, Sudevan, Surabhi, Higashitani, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body temperature Breakdown Breakdowns Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - antagonists & inhibitors Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Calcium Calcium (mitochondrial) Calcium (reticular) Calcium - metabolism Calcium homeostasis Calcium Signaling Damage accumulation Dantrolene - pharmacology Degeneration Endoplasmic reticulum Fever Forkhead protein Forkhead Transcription Factors - antagonists & inhibitors Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Fragmentation Genes Genetics Heat Heat stress Heat stroke Heat tolerance Heat treatment Heat-Shock Response Heatstroke High temperature Homeostasis In vivo methods and tests Investigations Ionomycin Ionomycin - pharmacology Life span Mammals Mitochondria Mitochondria, Muscle - drug effects Mitochondria, Muscle - metabolism Morphology Muscles Musculoskeletal system Mutation Myofibrils - metabolism Nematodes Proteins Receptor, Insulin Resistance factors Rhabdomyolysis Rodents Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine receptors Sarcoplasmic reticulum Skeletal muscle Temperature effects Transcription factors Worms
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