Maternal Smoking and Oral Clefts: The Role of Detoxification Pathway Genes
Background: There is evidence for an effect of cigarette smoking on risk of oral clefts. There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke. Methods: We performed a combined case-control and family-triad study of babies born with oral clefts in No...
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| Veröffentlicht in: | Epidemiology (Cambridge, Mass.) Mass.), 2008-07, Vol.19 (4), p.606-615 |
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| creator | Lie, Rolv T. Wilcox, Allen J. Taylor, Jack Gjessing, Håkon K. Saugstad, Ola Didrik Aabyholm, Frank Vindenes, Halvard |
| description | Background: There is evidence for an effect of cigarette smoking on risk of oral clefts. There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke. Methods: We performed a combined case-control and family-triad study of babies born with oral clefts in Norway in the period 1996 to 2001, with 88% participation among cases (n = 573) and 76% participation among controls (n = 763). Mothers completed a questionnaire 4 months after birth of the baby. DNA was collected from parents and children, and assayed for genes related to detoxification of compounds of cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, and GSTM1). Results: For isolated cleft lip (with or without cleft palate) there was a dose-response effect of smoking in the first trimester. The odds ratio rose from 1.6 (95% confidence interval = 1.0–2.5) for passive smoking to 1.9 (0.9–4.0) for mothers who smoked more than 10 cigarettes per day. There was little evidence of an association with cleft palate. Genetic analyses used both case-control and family-triad data. In case-triads we found an association between a NAT2 haplotype and isolated cleft lip (relative risk of 1.6 with 1 copy of the allele and 2.5 with 2 copies), but with little evidence of interaction with smoking. Other genes did not show associations, and previously described interactions with smoking were not confirmed. Conclusion: First-trimester smoking was clearly associated with risk of cleft lip. This effect was not modified by variants of genes related to detoxification of compounds of cigarette smoke. |
| doi_str_mv | 10.1097/EDE.0b013e3181690731 |
| format | Article |
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There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke. Methods: We performed a combined case-control and family-triad study of babies born with oral clefts in Norway in the period 1996 to 2001, with 88% participation among cases (n = 573) and 76% participation among controls (n = 763). Mothers completed a questionnaire 4 months after birth of the baby. DNA was collected from parents and children, and assayed for genes related to detoxification of compounds of cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, and GSTM1). Results: For isolated cleft lip (with or without cleft palate) there was a dose-response effect of smoking in the first trimester. The odds ratio rose from 1.6 (95% confidence interval = 1.0–2.5) for passive smoking to 1.9 (0.9–4.0) for mothers who smoked more than 10 cigarettes per day. There was little evidence of an association with cleft palate. Genetic analyses used both case-control and family-triad data. In case-triads we found an association between a NAT2 haplotype and isolated cleft lip (relative risk of 1.6 with 1 copy of the allele and 2.5 with 2 copies), but with little evidence of interaction with smoking. Other genes did not show associations, and previously described interactions with smoking were not confirmed. Conclusion: First-trimester smoking was clearly associated with risk of cleft lip. This effect was not modified by variants of genes related to detoxification of compounds of cigarette smoke.</description><identifier>ISSN: 1044-3983</identifier><identifier>EISSN: 1531-5487</identifier><identifier>DOI: 10.1097/EDE.0b013e3181690731</identifier><identifier>PMID: 18449058</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins</publisher><subject>Adult ; Arylamine N-Acetyltransferase - genetics ; Biological and medical sciences ; BIRTH DEFECTS ; Case-Control Studies ; Children ; Cigarette smoking ; Cigarettes ; Cleft lip ; Cleft Lip - epidemiology ; Cleft Lip - etiology ; Cleft Lip - genetics ; Cleft palate ; Cleft Palate - epidemiology ; Cleft Palate - genetics ; Congenital Abnormalities - epidemiology ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Haplotypes ; Humans ; Infant, Newborn ; Medical sciences ; Middle Aged ; Miscellaneous ; Mothers ; Nicotiana - adverse effects ; Non tumoral diseases ; Norway - epidemiology ; Otorhinolaryngology. Stomatology ; Polymorphism, Single Nucleotide - genetics ; Pregnancy ; Pregnancy Trimester, First ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Questionnaires ; Risk Assessment ; Secondhand smoke ; Smoke - adverse effects ; Smoke - analysis ; Smoking - adverse effects ; Smoking - epidemiology ; Smoking - genetics ; Surveys and Questionnaires ; Tobacco smoking ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Epidemiology (Cambridge, Mass.), 2008-07, Vol.19 (4), p.606-615</ispartof><rights>Copyright ©2008 Lippincott Williams & Wilkins</rights><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4377-1f65046dde12dc764f5923c956a586393c421cbd368d089492a01eef7b5accfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25662594$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25662594$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20458324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18449058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lie, Rolv T.</creatorcontrib><creatorcontrib>Wilcox, Allen J.</creatorcontrib><creatorcontrib>Taylor, Jack</creatorcontrib><creatorcontrib>Gjessing, Håkon K.</creatorcontrib><creatorcontrib>Saugstad, Ola Didrik</creatorcontrib><creatorcontrib>Aabyholm, Frank</creatorcontrib><creatorcontrib>Vindenes, Halvard</creatorcontrib><title>Maternal Smoking and Oral Clefts: The Role of Detoxification Pathway Genes</title><title>Epidemiology (Cambridge, Mass.)</title><addtitle>Epidemiology</addtitle><description>Background: There is evidence for an effect of cigarette smoking on risk of oral clefts. There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke. Methods: We performed a combined case-control and family-triad study of babies born with oral clefts in Norway in the period 1996 to 2001, with 88% participation among cases (n = 573) and 76% participation among controls (n = 763). Mothers completed a questionnaire 4 months after birth of the baby. DNA was collected from parents and children, and assayed for genes related to detoxification of compounds of cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, and GSTM1). Results: For isolated cleft lip (with or without cleft palate) there was a dose-response effect of smoking in the first trimester. The odds ratio rose from 1.6 (95% confidence interval = 1.0–2.5) for passive smoking to 1.9 (0.9–4.0) for mothers who smoked more than 10 cigarettes per day. There was little evidence of an association with cleft palate. Genetic analyses used both case-control and family-triad data. In case-triads we found an association between a NAT2 haplotype and isolated cleft lip (relative risk of 1.6 with 1 copy of the allele and 2.5 with 2 copies), but with little evidence of interaction with smoking. Other genes did not show associations, and previously described interactions with smoking were not confirmed. Conclusion: First-trimester smoking was clearly associated with risk of cleft lip. This effect was not modified by variants of genes related to detoxification of compounds of cigarette smoke.</description><subject>Adult</subject><subject>Arylamine N-Acetyltransferase - genetics</subject><subject>Biological and medical sciences</subject><subject>BIRTH DEFECTS</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Cigarette smoking</subject><subject>Cigarettes</subject><subject>Cleft lip</subject><subject>Cleft Lip - epidemiology</subject><subject>Cleft Lip - etiology</subject><subject>Cleft Lip - genetics</subject><subject>Cleft palate</subject><subject>Cleft Palate - epidemiology</subject><subject>Cleft Palate - genetics</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mothers</subject><subject>Nicotiana - adverse effects</subject><subject>Non tumoral diseases</subject><subject>Norway - epidemiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Questionnaires</subject><subject>Risk Assessment</subject><subject>Secondhand smoke</subject><subject>Smoke - adverse effects</subject><subject>Smoke - analysis</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Smoking - genetics</subject><subject>Surveys and Questionnaires</subject><subject>Tobacco smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>1044-3983</issn><issn>1531-5487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9vEzEQxS0Eom3gGwDaC71tGa__rM0BCaWhgIqKoJwtxzvubuusi70h9NtjSNQAvthj_96bkR8hzyicUNDtq8Xp4gSWQBkyqqjU0DL6gBxSwWgtuGofljNwXjOt2AE5yvkagBZGPCYHVHGuQahD8vGTnTCNNlRfV_FmGK8qO3bVRSoX84B-yq-ryx6rLzFgFX11ilP8OfjB2WmIY_XZTv3G3lVnOGJ-Qh55GzI-3e0z8u3d4nL-vj6_OPswf3teO87atqZeCuCy65A2nWsl90I3zGkhrVCSaeZ4Q92yY1J1oDTXjQWK6NulsM75js3Im63v7Xq5ws7hOJVxzW0aVjbdmWgH8-_LOPTmKv4wQkgAJorB8c4gxe9rzJNZDdlhCHbEuM6moZyCbHQB-RZ0Keac0N83oWB-h2BKCOb_EIrsxd8D7kW7Xy_Ayx1gs7PBJzu6Id9zDfACNXzffxNDSSnfhPUGk-nRhqk3UBaVXNUNgIK2VDX8iXhGnm9l13mKaW8rpGyE5uwX4QypDA</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Lie, Rolv T.</creator><creator>Wilcox, Allen J.</creator><creator>Taylor, Jack</creator><creator>Gjessing, Håkon K.</creator><creator>Saugstad, Ola Didrik</creator><creator>Aabyholm, Frank</creator><creator>Vindenes, Halvard</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>200807</creationdate><title>Maternal Smoking and Oral Clefts: The Role of Detoxification Pathway Genes</title><author>Lie, Rolv T. ; Wilcox, Allen J. ; Taylor, Jack ; Gjessing, Håkon K. ; Saugstad, Ola Didrik ; Aabyholm, Frank ; Vindenes, Halvard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4377-1f65046dde12dc764f5923c956a586393c421cbd368d089492a01eef7b5accfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Arylamine N-Acetyltransferase - genetics</topic><topic>Biological and medical sciences</topic><topic>BIRTH DEFECTS</topic><topic>Case-Control Studies</topic><topic>Children</topic><topic>Cigarette smoking</topic><topic>Cigarettes</topic><topic>Cleft lip</topic><topic>Cleft Lip - epidemiology</topic><topic>Cleft Lip - etiology</topic><topic>Cleft Lip - genetics</topic><topic>Cleft palate</topic><topic>Cleft Palate - epidemiology</topic><topic>Cleft Palate - genetics</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mothers</topic><topic>Nicotiana - adverse effects</topic><topic>Non tumoral diseases</topic><topic>Norway - epidemiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Questionnaires</topic><topic>Risk Assessment</topic><topic>Secondhand smoke</topic><topic>Smoke - adverse effects</topic><topic>Smoke - analysis</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Smoking - genetics</topic><topic>Surveys and Questionnaires</topic><topic>Tobacco smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lie, Rolv T.</creatorcontrib><creatorcontrib>Wilcox, Allen J.</creatorcontrib><creatorcontrib>Taylor, Jack</creatorcontrib><creatorcontrib>Gjessing, Håkon K.</creatorcontrib><creatorcontrib>Saugstad, Ola Didrik</creatorcontrib><creatorcontrib>Aabyholm, Frank</creatorcontrib><creatorcontrib>Vindenes, Halvard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lie, Rolv T.</au><au>Wilcox, Allen J.</au><au>Taylor, Jack</au><au>Gjessing, Håkon K.</au><au>Saugstad, Ola Didrik</au><au>Aabyholm, Frank</au><au>Vindenes, Halvard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Smoking and Oral Clefts: The Role of Detoxification Pathway Genes</atitle><jtitle>Epidemiology (Cambridge, Mass.)</jtitle><addtitle>Epidemiology</addtitle><date>2008-07</date><risdate>2008</risdate><volume>19</volume><issue>4</issue><spage>606</spage><epage>615</epage><pages>606-615</pages><issn>1044-3983</issn><eissn>1531-5487</eissn><abstract>Background: There is evidence for an effect of cigarette smoking on risk of oral clefts. There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke. Methods: We performed a combined case-control and family-triad study of babies born with oral clefts in Norway in the period 1996 to 2001, with 88% participation among cases (n = 573) and 76% participation among controls (n = 763). Mothers completed a questionnaire 4 months after birth of the baby. DNA was collected from parents and children, and assayed for genes related to detoxification of compounds of cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, and GSTM1). Results: For isolated cleft lip (with or without cleft palate) there was a dose-response effect of smoking in the first trimester. The odds ratio rose from 1.6 (95% confidence interval = 1.0–2.5) for passive smoking to 1.9 (0.9–4.0) for mothers who smoked more than 10 cigarettes per day. There was little evidence of an association with cleft palate. Genetic analyses used both case-control and family-triad data. In case-triads we found an association between a NAT2 haplotype and isolated cleft lip (relative risk of 1.6 with 1 copy of the allele and 2.5 with 2 copies), but with little evidence of interaction with smoking. Other genes did not show associations, and previously described interactions with smoking were not confirmed. Conclusion: First-trimester smoking was clearly associated with risk of cleft lip. This effect was not modified by variants of genes related to detoxification of compounds of cigarette smoke.</abstract><cop>Philadelphia, PA</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18449058</pmid><doi>10.1097/EDE.0b013e3181690731</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Arylamine N-Acetyltransferase - genetics Biological and medical sciences BIRTH DEFECTS Case-Control Studies Children Cigarette smoking Cigarettes Cleft lip Cleft Lip - epidemiology Cleft Lip - etiology Cleft Lip - genetics Cleft palate Cleft Palate - epidemiology Cleft Palate - genetics Congenital Abnormalities - epidemiology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Haplotypes Humans Infant, Newborn Medical sciences Middle Aged Miscellaneous Mothers Nicotiana - adverse effects Non tumoral diseases Norway - epidemiology Otorhinolaryngology. Stomatology Polymorphism, Single Nucleotide - genetics Pregnancy Pregnancy Trimester, First Public health. Hygiene Public health. Hygiene-occupational medicine Questionnaires Risk Assessment Secondhand smoke Smoke - adverse effects Smoke - analysis Smoking - adverse effects Smoking - epidemiology Smoking - genetics Surveys and Questionnaires Tobacco smoking Tobacco, tobacco smoking Toxicology |
| title | Maternal Smoking and Oral Clefts: The Role of Detoxification Pathway Genes |
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