Osteosarcoma: Molecular Pathogenesis and iPSC Modeling

Rare hereditary disorders provide unequivocal evidence of the importance of genes in human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis are invaluable in understanding the underlying genetics of this malignancy. Recently, patient-derived induced pluripotent stem ce...

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Veröffentlicht in:	Trends in molecular medicine 2017-08, Vol.23 (8), p.737-755
Hauptverfasser:	Lin, Yu-Hsuan, Jewell, Brittany E., Gingold, Julian, Lu, Linchao, Zhao, Ruiying, Wang, Lisa L., Lee, Dung-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology cancer etiology familial cancer syndrome Humans induced pluripotent stem cell Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Li-Fraumeni Syndrome - genetics Li-Fraumeni Syndrome - metabolism Li-Fraumeni Syndrome - pathology Models, Biological osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology
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