Riboflavin-containing telodendrimer nanocarriers for efficient doxorubicin delivery: High loading capacity, increased stability, and improved anticancer efficacy

We have developed two linear-dendritic telodendrimers (TDs) with rational design using amphiphilic riboflavin (Rf) as building blocks for efficient doxorubicin (DOX) delivery. Micellar TD nanoparticles (NPs) are composed of a hydrophilic polyethylene glycol (PEG) shell and a Rf-containing affinitive...

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Veröffentlicht in:	Biomaterials 2017-10, Vol.141, p.161-175
Hauptverfasser:	Guo, Dandan, Shi, Changying, Wang, Xu, Wang, Lili, Zhang, Shengle, Luo, Juntao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - therapeutic use Cancer treatment Cell Line, Tumor Controlled drug release Delayed-Action Preparations - chemistry Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Female High loading capacity Humans Mice Mice, Inbred BALB C Neoplasms - drug therapy Neoplasms - pathology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Rational nanocarrier design Riboflavin - chemistry Surface-Active Agents - chemistry Targeted therapy Telodendrimer
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